Allotopic expression

Allotopic expression

Allotopic expression (AE) refers to expression from the nuclear genome of genes that normally are expressed only from the mitochondrial genome. Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases (de Grey 2000), however this view is controversial (Oca-Cossio et al 2003).

References

* de Grey, Aubrey D. N. J. (2000): Mitochondrial gene therapy: an arena for the biomedical use of inteins. "Trends in Biotechnology" 18(9): 394-399 DOI|10.1016/S0167-7799(00)01476-1 (HTML abstract)
* Oca-Cossio et al, Limitations of allotopic expression of mitochondrial genes in mammalian cells. "Genetics". 2003 Oct;165(2):707-20 [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14573482] (abstract & full article)


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Strategies for Engineered Negligible Senescence — (SENS) is the name Aubrey de Grey gives to his proposal to research regenerative medical procedures to periodically repair all the age related damage in the human body, thereby maintaining a youthful state indefinitely.[1][2] The term first… …   Wikipedia

  • Mitochondrial disease — Classification and external resources Micrograph showing ragged red fibres, a finding seen in mitochondrial diseases. Muscle biopsy. Gomori trichrome stain …   Wikipedia

  • Intein — An intein is a segment of a protein that is able to excise itself and rejoin the remaining portions (the exteins) with a peptide bond. Inteins have also been called protein introns . [cite journal |author=Anraku Y, Mizutani R, Satow Y… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”