MCEF

protein
Name=AF4/FMR2 family, member 4
caption=


width=
HGNCid=17869
Symbol=AFF4
AltSymbols=
EntrezGene=27125
OMIM=604417
RefSeq=NM_014423
UniProt=Q9UHB7
PDB=
ECnumber=
Chromosome=5
Arm=q
Band=31
LocusSupplementaryData=

MCEF or Major Cdk9-interacting elongation factor is a transcription factor related to Af4. It is the fourth member of the Af4 family (AFF) of trancription factors, involved in numerous pathologies, including Acute Lymphoblastic Leukemia (ALL), abnormal CNS development, breast cancer and azoospermia.

Because it apparently interacts with the species-specific human co-factor (P-TEFb) for HIV-1 transcription, and because it can repress HIV-1 replication, MCEF (also known as AFF4 or AF5q31) may have future therapeutic uses.cite journal |author=Estable M, Naghavi M, Kato H, Xiao H, Qin J, Vahlne A, Roeder R |title=MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein |journal=J Biomed Sci |volume=9 |issue=3 |pages=234–245 |year=2002 |pmid=12065898 |doi=10.1007/BF02256070]

MCEF was originally cloned and named by Mario Clemente Estable of Ryerson University, while he was a post-doctoral fellow in the laboratory of Robert G. Roeder, at the Rockefeller University.

ee also

Transcription factors

References

*cite journal |author=Niedzielski MF, Hopewell R, Ismail Z, Estable MC |title=MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription |journal=Int J Biol Sci |volume=3 |issue=4 |pages=225–236 |year=2007
*