Brushfield spots

Brushfield spots

Brushfield spots are small white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of a normal iris element (connective tissue). These spots are normal in children but are also a feature of the chromosomal disorder Down syndrome. They occur in 35-78% of newborn infants with Down syndrome. [Citation
last=Sanez
first=R.B.
title= Primary care of infants and young children with down syndrome.
newspaper=American Family Physician
volume=59
issue=2
year=1999
date=January 1999
url=http://www.aafp.org/afp/990115ap/381.html] They are much more likely to occur in Down syndrome children of the Caucasian race than children of Asian heritage. [Citation
last=Kim
first=J.H. et al
title= Characteristic ocular findings in Asian children with Down syndrome.
newspaper=Nature
volume=16
issue=6
year=2002
date=November 2002
url=http://www.nature.com/eye/journal/v16/n6/abs/6700208a.html] Brushfield spots are named after the physician, Thomas Brushfield, who first described them in 1924Fact|date=January 2008.

They are focal areas of stromal hyperplasia, surrounded by relative hypoplasia and are more common in patients with lightly pigmented irises.

References


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  • Brushfield-Spots — (deutsch: Brushfield Flecken), auch Brushfieldspots geschrieben und unter dem Synonym Brushfield Iris Sprenkelung bekannt, sind durch eine Anhäufung von Stromafasern entstandene ophthalmologische Gewebeveränderungen / Pigmentbesonderheiten in den …   Deutsch Wikipedia

  • Brushfield spots — greyish brown spots seen in the iris of the eye. They can be found in normal individuals but are usually associated with Down s syndrome. T. Brushfield (1858 1937), British physician * * * Brush·field spots (brushґfēld) [Thomas Brushfield,… …   Medical dictionary

  • Brushfield spots — greyish brown spots seen in the iris of the eye. They can be found in normal individuals but are usually associated with Down s syndrome. [Brushfield (1858–1937), British physician] …   The new mediacal dictionary

  • Brushfield-Iris-Sprenkelung — Brushfield Spots Brushfield Spots (deutsch: Brushfield Flecken), auch Brushfieldspots geschrieben und unter dem Synonym Brushfield Iris Sprenkelung bekannt, sind durch eine Anhäufung von Stromafasern entstandene ophthalmologische… …   Deutsch Wikipedia

  • Brushfield’s spots — Speckled iris. Little white spots that slightly elevated on the surface of the iris arranged in a ring concentric with the pupil. These spots occur in normal children but are far more frequent in Down’s syndrome (trisomy 21). They were described… …   Medical dictionary

  • Spots, Brushfield’s — Speckled iris. Little white spots that slightly elevated on the surface of the iris and are arranged in a ring concentric with the pupil. These spots occur in normal children but are far more frequent in Down’s syndrome (trisomy 21). They were… …   Medical dictionary

  • Brushfield — Thomas, British physician, 1858–1937. See B. spots, under spot, B. Wyatt disease …   Medical dictionary

  • Brushfieldspots — Brushfield Spots Brushfield Spots (deutsch: Brushfield Flecken), auch Brushfieldspots geschrieben und unter dem Synonym Brushfield Iris Sprenkelung bekannt, sind durch eine Anhäufung von Stromafasern entstandene ophthalmologische… …   Deutsch Wikipedia

  • Down syndrome — Classification and external resources Boy with Down syndrome assembling a …   Wikipedia

  • Downsyndrom — Achtjähriger Junge mit Trisomie 21 Als Down Syndrom bezeichnet man eine spezielle Genommutation beim Menschen, bei der das gesamte 21. Chromosom oder Teile davon dreifach (Trisomie) vorliegen. Daher lautet eine weitere übliche Bezeichnung… …   Deutsch Wikipedia

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