- Koplik's spots
Koplik's spots (kop'liks) are small, irregular, red spots with a minute bluish white speck in the center of each seen on the buccal mucosa and lingual mucosa (
mucous membraneof the inside of the cheek and tongue) and are pathognomonicof early stage measles. They are named after Henry Koplik(1858-1927), an American pediatricianwho first described them in 1896.
They often appear a few days before the rash arrives and can be a useful sign to look for in children known to be exposed to the
The first description of these spots by some authors are ascribed to Reubold, Würzburg 1854, by others to Johann Andreas Murray (1740-1791). Before Koplik, the German internist
Carl Jakob Adolf Christian Gerhardt(1833-1902) in 1874, the Danish physician N. Flindt in 1879, and the Russian Nicolai Feodorowitsch von Filatov (1847-1902) in 1897, had observed equivalent phenomena.Koplik, H. The diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membrane. Archives of Pediatrics, New York, 1896; 13: 918-922." (accessed from http://www.whonamedit.com/synd.cfm/1437.html on 9/13/2006)]
* [http://www.dentistry.leeds.ac.uk/oralpath/viruses/viral%20infections/340%20images/other%20viral%20images/koplik%27s%20spots.jpgImage of Koplik's spots] - dentistry.leeds.ac.uk.
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