Ruzicka large ring synthesis
- Ruzicka large ring synthesis
The Ruzicka large ring synthesis or Ruzicka reaction or Ruzicka cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone at high temperature and a suitable catalyst such as thorium oxide. The reaction is named after Lavoslav Ružička who invented it in 1926. [cite journal
title = Zur Kenntnis des Kohlenstoffringes II. Synthese der carbocyclischen Ketone vom Zehner- bis zum Achtzehnerring
author = L. Ruzicka, M. Stoll, H. Schinz
journal = Helvetica Chimica Acta
year = 1926
volume = 9
issue = 1
pages = 249–264
doi = 10.1002/hlca.19260090130 ]
The reaction has been applied in the synthesis of Exaltone, a synthetic Muscone.
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