- Bisoctrizole
Chembox new
Name = Bisoctrizole
ImageFile = Bisoctrizole.svg
ImageName = Bisoctrizole
IUPACName = 2,2'-methylenebis [6-(2"H"-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]
Section1 = Chembox Identifiers
CASNo = 103597-45-l
Section2 = Chembox Properties
Formula = C41H50N6O2
MolarMass = 658.89 g/mol
MeltingPt = 195.7 °CBisoctrizole (INN [http://whqlibdoc.who.int/druginfo/18_4_2004_INN92.pdf] [http://whqlibdoc.who.int/druginfo/INN_2005_list54.pdf] /USAN [http://www.ama-assn.org/ama1/pub/upload/mm/365/bisoctrizol.doc] , marketed by
Ciba Specialty Chemicals as Tinosorb M,INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is abenzotriazole basedorganic compound which is added tosunscreen s to absorb UV rays.Bisoctrizole is a broad
spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV. Bisoctrizole is a hybrid UV absorber, the first and only organic UV filter produced as microfine organic particles (< 200 nm), [ [http://www.ciba.com/index/ind-index/ind-per_car/skin_care___sun_care_actives/tinosorb-registered-_uv_filters/tinosorb-registered-_m-2.htm Ciba TINOSORB M] ] [ [http://www.blackwell-synergy.com/doi/abs/10.1046/j.1467-2494.2002.00137.x Blackwell Synergy - Int J Cosmet Sci, Volume 24 Issue 3 Page 170-185, June 2002 (Article Abstract) ] ] like microfinezinc oxide andtitanium dioxide . Where other organic UV absorbers need to be dissolved in either the oil or water phase, bisoctrizole dissolves poorly in both.Bisoctrizole is added to the water phase of a sunscreen as a 50% suspension, while mineral micropigments are usually added to the oil phase. The bisoctrizole particles are stabilized by the
surfactant decyl glucoside .Bisoctrizole shows very little
photodegradation and has a stabilizing effect on other UV absorbers,octyl methoxycinnamate (octinoxate) in particular.When formulated into a sunscreen bisoctrizole has minimal skin penetration. [cite journal| title=In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen| year=2007| pmid=17035717| author=Mavon A, Miquel C, Lejeune O, Payre B, Moretto P| journal=Skin Pharmacol Physiol| volume=20(1)| pages=10–20| doi=10.1159/000096167] Unlike some other organic sunscreen actives, it shows no estrogenic effects
in vitro . [cite journal| title=Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S| year=2001| month=Dec| pmid=11754532| author=Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA| journal= Regul Toxicol Pharmacol| volume=34(3)| pages=287–91| doi=10.1006/rtph.2001.1511]Bisoctrizole is not approved by the
FDA , but is approved in the EU and other parts of the world. [ [http://www.modernmedicine.com/modernmedicine/article/articleDetail.jsp?id=169626 Manage Account - Modern Medicine ] ] [ [http://eur-lex.europa.eu/LexUriServ/site/en/consleg/1976/L/01976L0768-20060809-en.pdf CL1976L0768EN0150010.0001 1..107 ] ] [ [http://www.tga.gov.au/docs/pdf/argom_10.pdf Australian Regulatory Guidelines for OTC Medicines - Chapter 10 ] ]ee also
*
Sunscreen
*Avobenzone
*Bemotrizinol
*Bisdisulizole disodium
*Ecamsule References
External links
* http://www.cibasc.com/index/ind-index/ind-per_car/ind-pc-uv/ind-pc-uv-tinosorbm.htm
* http://www.dermatologytimes.com/dermatologytimes/article/articleDetail.jsp?id=159652
* http://pubs.acs.org/cen/coverstory/83/8315sunscreens.html
* http://www.fda.gov/ohrms/dockets/dockets/05n0446/05n-0446-bkg0001-03-Tab-01-vol2.pdf
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