Anisomycin

Chembox new
Reference= [ [http://www.fermentek.co.il/anisomycin.htm Anisomycin] from Fermentek]
ImageFile=Anisomycin structure.pngImageSize=200px
IUPACName= [(2"S",3"R",4"R")-4-Hydroxy-2- [(4-methoxyphenyl)methyl] pyrrolidin-3-yl] acetate
OtherNames=Flagecidin
Section1= Chembox Identifiers
CASNo=22862-76-6
PubChem=31549
SMILES=CC(=O)O [C@H] 1 [C@@H] (CN [C@H] 1CC2=CC=C(C=C2)OC)O
Section2= Chembox Properties
Formula=C₁₄H₁₉NO₄
MolarMass=265.31 g/mol
MeltingPt=139-143 °C
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Anisomycin, also known as flagecidin is an antibiotic produced by "Streptomyces griseolus" which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. [ pathways.

Anisomycin is inactive against bacteria.

Pharmacology

Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories.". [cite journal |author=Barrientos RM, O'Reilly RC, Rudy JW |title=Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration |journal=Behav. Brain Res. |volume=134 |issue=1-2 |pages=299–306 |date=2002 Aug 21 |pmid=12191817 |doi=10.1016/S0166-4328(02)00045-1]

Injection of anisomycin into the hippocampus has been proposed for selective removal of memories. [ cite journal |author=Wang SH, Ostlund SB, Nader K, Balleine BW |title=Consolidation and reconsolidation of incentive learning in the amygdala |journal=J. Neurosci. |volume=25 |issue=4 |pages=830–5 |year=2005 |pmid=15673662 |doi=10.1523/JNEUROSCI.4716-04.2005 [http://www.jneurosci.org/cgi/content/full/25/4/830 Free text] ]

ee also

* Cycloheximide

References