Kayser-Fleischer ring

Kayser-Fleischer ring

Infobox_Disease
Name = Kayser-Fleischer ring


Caption = A Kayser-Fleischer ring in a 32-year-old patient who had longstanding speech difficulties and tremor.
DiseasesDB = 30056
ICD10 = ICD10|H|18|0|h|15
ICD9 = ICD9|371.14
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
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Kayser-Fleischer rings (KF rings) are dark rings that appear to encircle the iris of the eye. They are due to copper deposition as a result of particular liver diseases. They are named after Dr Bernhard Kayser and Dr Bruno Fleischer, the German doctors who first described them in 1902 and 1903. [cite journal | author=Kayser B | title=Über einen Fall von angeborener grünlicher Verfärbung des Cornea | journal=Klin Monatsbl Augenheilk | year=1902 | volume=40 | issue=2 | pages=22–25] [cite journal | author=Fleischer B | title=Zwei weitere Fälle von grünlicher Verfärbung der Kornea | journal=Klin Monatsbl Augenheilk | year=1903 | volume=41 | issue=1 | pages=489–491] [WhoNamedIt|synd|1758] Initially thought to be due to the accumulation of silver, they were first demonstrated to contain copper in 1934. [cite journal | author=Gerlach W, Rohrschneider W | title=Besteht das Pigment des Kayser-Fleischerschen Hornhautringes aus Silber? | journal=Klin Wochenschr | year=1934 | volume=13 | pages=48–49 | doi=10.1007/BF01799043]

Detection

As Kayser-Fleischer rings do not cause any symptoms, it is common for them to be identified during investigations for other medical conditions. In certain situations, they are actively sought; in that case, the early stages may be detected by slit lamp examination before they become visible to the naked eye.cite journal |author=McDonnell G, Esmonde T |title=A homesick student |journal=Postgrad Med J |volume=75 |issue=884 |pages=375–8 |year=1999 |pmid=10435182 | url=http://pmj.bmj.com/cgi/content/full/75/884/375]

Appearance

The rings, which consist of copper deposits where the cornea meets the sclera, in Descemet's membrane, first appear as a crescent at the top of the cornea. Eventually, a second crescent forms below, at 6 o'clock, and ultimately completely encircles the cornea. [GPnotebook|-1684406263]

Associations

Kayser-Fleischer rings are a sign of Wilson's disease, which involves abnormal copper handling by the liver resulting in copper accumulation in the body and is characterised by abnormalities of the basal ganglia of the brain, liver cirrhosis, splenomegaly, involuntary movements, muscle rigidity, psychiatric disturbances, dystonia and dysphagia. The combination of neurological symptoms, a low blood ceruloplasmin level and KF rings is diagnostic of Wilson's disease.

Other causes of KF rings are cholestasis (obstruction of the bile ducts), primary biliary cirrhosis and "cryptogenic" cirrhosis (cirrhosis in which no cause can be identified).

References


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Look at other dictionaries:

  • Kayser-Fleischer-Ring — Kayser Fleischer Kornealring Der Kayser Fleischer Kornealring (Kornea = Hornhaut) ist eine Veränderung der Hornhaut des Auges im Zuge des Morbus Wilson, einer vererbten Stoffwechselstörung mit Kupferüberladung des Körpers. Am Rand der Hornhaut… …   Deutsch Wikipedia

  • Kayser-Fleischer ring — Kay·ser Flei·scher ring kī zər flī shər .riŋ n a brown or greenish brown ring of copper deposits around the cornea that is characteristic of Wilson s disease Kayser Bernhard (1869 1954), and Fleischer Bruno Otto (1874 1965) German… …   Medical dictionary

  • Kayser-Fleischer ring — a brownish yellow ring in the outer rim of the cornea of the eye. It is a deposit of copper granules and is diagnostic of Wilson s disease. When well developed it can be seen by unaided observation, but faint Kayser Fleischer rings may only be… …   The new mediacal dictionary

  • Kayser-Fleischer-Ring — Ka̲y̲|ser Fle̲i̲|scher Ring [nach den dt. Ophthalmologen Bernhard Kayser (1869 bis 1954) u. Bruno Fleischer (geb. 1874)]: gelblicher bis bräunlich grüner, stets doppelseitiger Ring aus Pigmentablagerungen in den tiefsten Schichten der Hornhaut… …   Das Wörterbuch medizinischer Fachausdrücke

  • Kayser-Fleischer ring — noun a pigmented ring at the outer edge of the cornea of the eye; a symptom of Wilson s disease • Hypernyms: ↑symptom …   Useful english dictionary

  • Kayser–Fleischer ring — …   Useful english dictionary

  • Kayser-Fleischer-Kornealring — Der Kayser Fleischer Kornealring (Kornea = Hornhaut) ist eine Veränderung der Hornhaut des Auges im Zuge des Morbus Wilson, einer vererbten Stoffwechselstörung mit Kupferüberladung des Körpers. Am Rand der Hornhaut bildet sich hierbei ein… …   Deutsch Wikipedia

  • Fleischer ring — Fleischer rings are pigmented rings in the peripheral cornea, resulting from iron deposition in basal epithelial cells. They are usually yellowish to dark brown, and may be complete or broken.Fleischer rings are indicative of keratoconus, a… …   Wikipedia

  • anillo de Kayser-Fleischer — Eng. Kayser Fleischer ring Depósito de cobre en la periferia corneal a nivel de la membrana de Descemet constituyendo un anillo dorado verdoso que aparece en pacientes afectos de enfermedad de Wilson o degeneración hepatolenticular. Signo de… …   Diccionario de oftalmología

  • Кольцо Кайзера-Фляйшера (Kayser-Fleischer Ring) — кольцо коричневато желтоватого цвета, образующееся на наружном крае роговицы глаза. Оно состоит из отложений медных гранул и диагностируется при наличии у человека болезни Вильсона. В случае хорошо развитых колец они могут быть обнаружены при… …   Медицинские термины

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