Section1= Chembox Identifiers
SMILES=COC [C@] 12CN(C) [C@@H] 3 [C@H] 4 [C@H] (OC)C1 [C@@] 3( [C@H] (C [C@H] 2O)OC) [C@@H] 5C [C@] 6 (O) [C@@H] (OC) [C@H] (O) [C@@] 4(OC(C)=O) [C@H] 5C6OC(=O)c7ccccc7
Section2= Chembox Properties
Section3= Chembox Hazards
Aconitine is a highly
poisonous alkaloidderived from various aconite species. It is a neurotoxinthat opens TTX-sensitive Na+ channels in the heartand other tissues, and is used for creating models of cardiac arrhythmia. Aconitine was previously used as an antipyretic.
Merck Indexgives LD50s for mice: 0.166 mg/kg ( intravenously); 0.328 mg/kg intraperitoneally (injected into the body cavity); approx. 1 mg/kg orally (ingested). [aut|Merck & Co. (1989): "The Merck Index. Eleventh Edition": p.117. Rahway, N.J.. ISBN 091191028X ] In rats, the oral LD50 is given as 5.97 mg/kg. Oral doses as low as 1.5 – 6 mg aconitine were reported to be lethal in humans. [aut|Ludewig, R., Regenthal, R. et al. (2007): Akute Vergiftungen und Arzneimittelüberdosierungen (German). ISBN 3-8047-2280-6]
It is quickly absorbed via
mucous membranes, but also via skin. Respiratory paralysis, in very high doses also cardiac arrest, leads to death. A few minutes after ingestion paresthesiastarts, which includes tingling in the oral region. This extends to the whole body, starting from the extremities. Anesthesia, sweating and cooling of the body, nausea and vomiting and other similar symptoms follow. Sometimes there is strong pain, accompanied by cramps, or diarrhea. There is no antidote, so only the symptoms can be treated. [aut|Roth, L., Daunderer, M. & Kormann, K. (1994): "Giftpflanzen - Pflanzengifte". ISBN 3-933203-31-7]
Aconitine was probably made most famous by its use in
Oscar Wilde's 1891 story "Lord Arthur Savile's Crime".
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