Pyrophosphate dependent phosphofructokinase

Pyrophosphate dependent phosphofructokinase

Protbox
Name=Pyrophosphate: D-Fructose-6-phosphate 1-phosphotransferase
Photo=Phosphofructokinase 6PFK wpmp.pngCaption=Bacillus stearothermophilus phosphofructokinase
width=250
AltSymbols=PFP, PPi-PFK
HGNCid=
Symbol=
Chromosome=
Arm=
Band=1
LocusSupplementaryData=
Gene=
Gene_type=
Protein_length=
Molecular_weight=α-subunit: 66000 (Da)
β-subunit: 60000
Structure=
Type=
Functions= Glycolytic/gluconeogenic
Domains=
Motifs=
Alternative_products=
Catalytic_activity=Fructose-6-phosphate + PPi ←→ Fructose-1,6-bisphosphate + Pi
Cofactors=Mg2+
Enzyme_regulation=Substrates/Products
Fructose-2,6-bisphosphate
Km=
Vmax=
Biophysicochemical_properties=
Diseases=
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Biotechnology=
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Cells=
Location=Cytosol
Mods=
Names=PFP, PPi-PFK, pyrophosphate dependent phosphofructokinase
Pathways=Glycolysis/Gluconeogenesis
Interactions=
Actions=
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Antagonists=
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OMIM=
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UniProt=
PDB =
ECnumber=2.7.1.90
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Pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90, PFP) is an exclusively cytosolic enzyme that catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate in the glycolytic direction, and the de-phosphorylation of fructose-1,6-bisphoshate to fructose-6-phosphate in the gluconeogenic reaction. Reeves et al. (1974) first isolated PFP from "Entamoeba histolytica", a lower eukaryote. The first plant PFP isolated was from the leaves of pineapples by Carnal and Black (1979) and it has since been isolated from a variety of plant species and tissues (Stitt 1990).

References

*Carnal NW, Black CC. (1979) Pyrophosphate-dependent 6-phosphofructokinase, a new glycolytic enzyme in pineapple leaves. "Biochemical and biophysical research communications" 86:20-26.
*Reeves RE, South DJ, Blytt HT, Warren LG. (1974) Pyrophosphate: D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase. "Journal of Biological Chemistry" 249:7737-7741. [http://www.jbc.org/cgi/reprint/249/24/7737 PDF/Abstract]
*Stitt M. (1990) Fructose-2,6-bisphosphate as a regulatory molecule in plants. "Annual Review of Plant Physiology and Plant Molecular Biology" 41:153-185. [http://arjournals.annualreviews.org/doi/pdf/10.1146/annurev.pp.41.060190.001101 PDF/Abstract]


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