Amphiphysin

Amphiphysin

Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen), also known as AMPH, is a human gene.cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = ]

Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.

ee also

* AP180
* Epsin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lichte B, Veh RW, Meyer HE, Kilimann MW |title=Amphiphysin, a novel protein associated with synaptic vesicles. |journal=EMBO J. |volume=11 |issue= 7 |pages= 2521–30 |year= 1992 |pmid= 1628617 |doi=
*cite journal | author=Yamamoto R, Li X, Winter S, "et al." |title=Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14. |journal=Hum. Mol. Genet. |volume=4 |issue= 2 |pages= 265–8 |year= 1995 |pmid= 7757077 |doi=
*cite journal | author=David C, Solimena M, De Camilli P |title=Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 73–9 |year= 1994 |pmid= 8076697 |doi=
*cite journal | author=De Camilli P, Thomas A, Cofiell R, "et al." |title=The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer. |journal=J. Exp. Med. |volume=178 |issue= 6 |pages= 2219–23 |year= 1993 |pmid= 8245793 |doi=
*cite journal | author=David C, McPherson PS, Mundigl O, de Camilli P |title=A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 331–5 |year= 1996 |pmid= 8552632 |doi=
*cite journal | author=Grabs D, Slepnev VI, Songyang Z, "et al." |title=The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. |journal=J. Biol. Chem. |volume=272 |issue= 20 |pages= 13419–25 |year= 1997 |pmid= 9148966 |doi=
*cite journal | author=Butler MH, David C, Ochoa GC, "et al." |title=Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. |journal=J. Cell Biol. |volume=137 |issue= 6 |pages= 1355–67 |year= 1997 |pmid= 9182667 |doi=
*cite journal | author=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700–6 |year= 1997 |pmid= 9195986 |doi=
*cite journal | author=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319–22 |year= 1997 |pmid= 9280305 |doi=
*cite journal | author=Micheva KD, Ramjaun AR, Kay BK, McPherson PS |title=SH3 domain-dependent interactions of endophilin with amphiphysin. |journal=FEBS Lett. |volume=414 |issue= 2 |pages= 308–12 |year= 1997 |pmid= 9315708 |doi=
*cite journal | author=Wigge P, Köhler K, Vallis Y, "et al." |title=Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=8 |issue= 10 |pages= 2003–15 |year= 1997 |pmid= 9348539 |doi=
*cite journal | author=Floyd S, Butler MH, Cremona O, "et al." |title=Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. |journal=Mol. Med. |volume=4 |issue= 1 |pages= 29–39 |year= 1998 |pmid= 9513187 |doi=
*cite journal | author=Ramjaun AR, McPherson PS |title=Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |journal=J. Neurochem. |volume=70 |issue= 6 |pages= 2369–76 |year= 1998 |pmid= 9603201 |doi=
*cite journal | author=Slepnev VI, Ochoa GC, Butler MH, "et al." |title=Role of phosphorylation in regulation of the assembly of endocytic coat complexes. |journal=Science |volume=281 |issue= 5378 |pages= 821–4 |year= 1998 |pmid= 9694653 |doi=
*cite journal | author=Cestra G, Castagnoli L, Dente L, "et al." |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001–7 |year= 1999 |pmid= 10542231 |doi=
*cite journal | author=Slepnev VI, Ochoa GC, Butler MH, De Camilli P |title=Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17583–9 |year= 2000 |pmid= 10748223 |doi= 10.1074/jbc.M910430199
*cite journal | author=Lee C, Kim SR, Chung JK, "et al." |title=Inhibition of phospholipase D by amphiphysins. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18751–8 |year= 2000 |pmid= 10764771 |doi= 10.1074/jbc.M001695200
*cite journal | author=Onofri F, Giovedi S, Kao HT, "et al." |title=Specificity of the binding of synapsin I to Src homology 3 domains. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29857–67 |year= 2000 |pmid= 10899172 |doi= 10.1074/jbc.M006018200
*cite journal | author=Lai MM, Luo HR, Burnett PE, "et al." |title=The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34017–20 |year= 2000 |pmid= 10931822 |doi= 10.1074/jbc.C000429200
*cite journal | author=Floyd SR, Porro EB, Slepnev VI, "et al." |title=Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8104–10 |year= 2001 |pmid= 11113134 |doi= 10.1074/jbc.M008932200
*Leventis PA, Chow BM, Stewart BA, Iyengar B, Campos AR, Boulianne GL. (2001). Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis. Traffic. 2(11):839-50.
*Zhang B, Zelhof AC. (2002). Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics. Traffic. 3(7):452-60. Review.
*Zelhof AC, Bao H, Hardy RW, Razzaq A, Zhang B, Doe CQ. (2001). Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis. Development. 128(24):5005-15.
*Mathew D, Popescu A, Budnik V. (2003). Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling. J Neurosci. 23(33):10710-6.

External links

* [http://www.endocytosis.org/Amphiphysin/amphiphysin.html Bringing your curves to the bar, amphiphysin home page]
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10559861&query_hl=3&itool=pubmed_docsum
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14645856&query_hl=1&itool=pubmed_docsum
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15180828&query_hl=3&itool=pubmed_docsum
*http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11711432&query_hl=6&itool=pubmed_docsum

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