Bridging integrator 1, also known as BIN1, is a human gene.

section_title =
summary_text = This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.cite web | title = Entrez Gene: BIN1 bridging integrator 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Negorev D, Riethman H, Wechsler-Reya R, "et al." |title=The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. |journal=Genomics |volume=33 |issue= 2 |pages= 329–31 |year= 1997 |pmid= 8725406 |doi= 10.1006/geno.1996.0205
*cite journal | author=Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC |title=BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. |journal=Nat. Genet. |volume=14 |issue= 1 |pages= 69–77 |year= 1996 |pmid= 8782822 |doi= 10.1038/ng0996-69
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Leprince C, Romero F, Cussac D, "et al." |title=A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15101–5 |year= 1997 |pmid= 9182529 |doi=
*cite journal | author=Butler MH, David C, Ochoa GC, "et al." |title=Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. |journal=J. Cell Biol. |volume=137 |issue= 6 |pages= 1355–67 |year= 1997 |pmid= 9182667 |doi=
*cite journal | author=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700–6 |year= 1997 |pmid= 9195986 |doi=
*cite journal | author=Tsutsui K, Maeda Y, Tsutsui K, "et al." |title=cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 1 |pages= 178–83 |year= 1997 |pmid= 9223448 |doi= 10.1006/bbrc.1997.6927
*cite journal | author=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319–22 |year= 1997 |pmid= 9280305 |doi=
*cite journal | author=Micheva KD, Ramjaun AR, Kay BK, McPherson PS |title=SH3 domain-dependent interactions of endophilin with amphiphysin. |journal=FEBS Lett. |volume=414 |issue= 2 |pages= 308–12 |year= 1997 |pmid= 9315708 |doi=
*cite journal | author=Micheva KD, Kay BK, McPherson PS |title=Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27239–45 |year= 1997 |pmid= 9341169 |doi=
*cite journal | author=Wigge P, Köhler K, Vallis Y, "et al." |title=Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=8 |issue= 10 |pages= 2003–15 |year= 1997 |pmid= 9348539 |doi=
*cite journal | author=Kadlec L, Pendergast AM |title=The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12390–5 |year= 1997 |pmid= 9356459 |doi=
*cite journal | author=Wechsler-Reya R, Sakamuro D, Zhang J, "et al." |title=Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31453–8 |year= 1998 |pmid= 9395479 |doi=
*cite journal | author=Wechsler-Reya RJ, Elliott KJ, Prendergast GC |title=A role for the putative tumor suppressor Bin1 in muscle cell differentiation. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 566–75 |year= 1998 |pmid= 9418903 |doi=
*cite journal | author=Ramjaun AR, McPherson PS |title=Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |journal=J. Neurochem. |volume=70 |issue= 6 |pages= 2369–76 |year= 1998 |pmid= 9603201 |doi=
*cite journal | author=Mao NC, Steingrimsson E, DuHadaway J, "et al." |title=The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2. |journal=Genomics |volume=56 |issue= 1 |pages= 51–8 |year= 1999 |pmid= 10036185 |doi= 10.1006/geno.1998.5709
*cite journal | author=Wixler V, Laplantine E, Geerts D, "et al." |title=Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains. |journal=FEBS Lett. |volume=445 |issue= 2-3 |pages= 351–5 |year= 1999 |pmid= 10094488 |doi=
*cite journal | author=Ramjaun AR, Philie J, de Heuvel E, McPherson PS |title=The N terminus of amphiphysin II mediates dimerization and plasma membrane targeting. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19785–91 |year= 1999 |pmid= 10391921 |doi=
*cite journal | author=Traub LM, Downs MA, Westrich JL, Fremont DH |title=Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 8907–12 |year= 1999 |pmid= 10430869 |doi=

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