Bloom-Richardson grade

Bloom-Richardson grade

The Bloom-Richardson grade (BR grade) is a a histologic grade assigned by pathologists to breast cancers. It is the most common type of cancer grade system currently used. It is a semi-quantitative grading method based on three morphologic features of invasive breast cancers. The morphologic features that are used are:

# degree of tumor tubule formation (percentage of cancer composed of tubular structures)
# tumor mitotic activity (rate of cell division)
# nuclear pleomorphism of tumor cells (nuclear grade, change in cell size and uniformity)

Each of these features is assigned a score ranging from 1 to 3. The scores are then added together for a final sum that will range between 3 to 9. This value is then used to grade the tumor as follows :

* 3-5 Grade 1 tumor (well-differentiated).
* 6-7 Grade 2 tumor (moderately-differentiated).
* 8-9 Grade 3 tumor (poorly-differentiated).

References

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