- Prothrombin complex concentrate
Prothrombin Complex Concentrate (PCC) (trade name Beriplex or Octaplex) is a combination of blood clotting factors II, VII, IX and X, as well as protein C and S. It reverses the effect of warfarin (a coumarin anti-coagulant) and is used in cases of significant bleeding in patients with a coagulopathy (INR > 8.0, prolonged prothrombin time, raised d-dimer). Examples include gastrointestinal haemorrhage or intracranial haemorrhage.
PCC is effective but expensive. In the UK is prescribed in discussion with a senior haematologist.
- ^ a b FASS.se (Farmaceutiska Specialiteter i Sverige - the Swedish official drug catalog) > Ocplex Last updated: 2009–09–03
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