3'-Cluster

3'-Cluster

A 3'-Cluster is a negative DNA sequence discovered by Singh and coworkers, using a technique known as in vivo selection of an entire exon.

The presence of 3'-Clusters prohibit the SMN2 gene from producing its normal proteins which can lead to Spinal muscular atrophy. 3'-Clusters in association with Exinct have been observed to cause aberrant splicing of exon 7, leading to the production of a short SMN transcript that makes a truncated non-functional SMN protein. Another regulatory element ISS-N1 has been also found to affect the aberrant splicing of exon 7. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16449646&query_hl=7&itool=pubmed_docsum] .

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