In vivo selection of an entire exon
- In vivo selection of an entire exon
"In vivo" selection of an entire exon is a powerful technique used by Singh and coworkers to identify novel regulatory elements within an exonic sequence that undergoes alternative splicing [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15272122&query_hl=6&itool=pubmed_docsum] . Thanks to "in vivo" selection of entire exon 7 of SMN gene, many regulatory elements could be identified. A knowledge of such elements are crucial for understanding the underlying cause of Spinal Muscular Atrophy, a devastating neuromuscular genetic disease of children and infants [http://en.wikipedia.org/wiki/Spinal_muscular_atrophy] .
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