Tuftsin

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CASNo=9063-57-4
PubChem=24780
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MeSHName=Tuftsin
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Formula=C₂₁H₄₀N₈O₆
MolarMass=500.593 g/mol
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Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) produced by enzymatic cleavage of the Fc-domain of the heavy chain of immunoglobulin G. It is produced primarily in the spleen.

Function

Its biological activity is related primarily to the immune system function.

Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation.

Pathology

Tuftsin deficiency, either hereditary or following splenectomy, results in increased susceptibility to certain infections. [OMIM|191150 - "Tuftsin deficiency"]

Clinical significance

Tuftsin has been chemically synthesized and it is considered for use in immunotherapy.

History

Tuftsin was first identified in 1970 by scientists Najjar and Nishioka [cite journal |author=Najjar V, Nishioka K |title="Tuftsin": a natural phagocytosis stimulating peptide |journal=Nature |volume=228 |issue=5272 |pages=672–3 |year=1970 |pmid=4097539 |url=http://www.nature.com/nature/journal/v228/n5272/abs/228672a0.html |doi=10.1038/228672a0 |format=abstract page ] . It was named after Tufts University where the peptide was discovered.

References

ee also

* Paraprotein