Grand-Santi

French commune|nomcommune=Grand-Santi
map_size=220px
adjustable_

mapcaption=Location of the commune (in red) within French Guiana
région=Guyane
département=Guyane
arrondissement=Saint-Laurent-du-Maroni
canton=
insee=97357
cp=97340
maire= Paul Martin
mandat= 2001-2008
intercomm=Communauté de communes de l'Ouest Guyanais
latitude = 4.273918
longitude = -54.382753
alt moy=
alt mini=
alt maxi=
km²=2,112
sans=3,276
date-sans=January 2005 census
dens=1.6
date-dens=2005|

Grand-Santi is a commune of French Guiana, an overseas "région" and "département" of France located in South America.

The commune was originally called Grand-Santi-Papaichton and included the now independent communes of Apatou and Papaichton. On November 12, 1976 Apatou was detached from Grand-Santi-Papaichton and became an independent commune. On January 1, 1993 Papaichton was also detached from Grand-Saint-Papaichton and became an independent commune. On that occasion, the name of the commune was shortened into Grand-Santi.