N-Acetyl procainamide

N-Acetyl procainamide

drugbox
N-acetylprocainamide
IUPAC_name = 4-acetylamino-"N"-(2-diethylaminoethyl)benzamide


CAS_number = 32795-44-1
ATC_prefix =
ATC_suffix =
ATC_supplemental =
PubChem = 4342
DrugBank =
C=15|H=23|N=3|O=2
molecular_weight = 277.36 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration = intravenously or orally

"N"-Acetylprocainamide (NAPA) (or acecainide) is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent.

It can be given either intravenously or orally, and is eliminated primarily by renal excretion. Comparative studies with other antiarrhythmic drugs have not been undertaken apart from a small study in atrial flutter where acecainide was better than quinidine plus digoxin. Thus, although further clinical experience is required before the relative place of acecainide in therapy can be determined, the drug nevertheless appears to offer advantages over procainamide, particularly with respect to the reduced formation of antinuclear antibodies.

References

*"Merck Index", 13th Edition, 20.
*Ger. Pat. , 1971, 2 062 978; CA , 75 , 76427, (Acecainide)


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Procainamide — Systematic (IUPAC) name 4 amino N (2 diethylaminoethyl) benzamide Clinical data AHFS/Drug …   Wikipedia

  • Antiarrhythmic agent — The cardiac action potential Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular …   Wikipedia

  • N-Acetylprocainamide — N Acetyl procainamide Systematic (IUPAC) name 4 acetylamino N (2 diethylaminoethyl)benzamide Clinical data Pregnancy cat …   Wikipedia

  • NAPA — N acetyl p aminophenol; N acetyl procainamide …   Medical dictionary

  • NAPA — abbr. med. N acetyl procainamide – N ацетилпрокаинамид med. N acetyl paraaminophenol – N ацетилпарааминофенол …   Dictionary of English abbreviation

  • NAPA — • N acetyl p aminophenol; • N acetyl procainamide …   Dictionary of medical acronyms & abbreviations

  • Napa (disambiguation) — Napa is is the county seat of Napa County, California.Napa may also refer to: *Napa County, California *Napa cabbage, a type Chinese cabbage *Napa leather or Nappa leather, a type of full grained sheep leather *Napa platform, one of Intel… …   Wikipedia

  • Napa — may refer to: Napa, California, the county seat of Napa County Napa County, California, United States Napa cabbage, a type of Chinese cabbage Napa leather or Nappa leather, a type of full grained sheep leather Napa platform, one of Intel s… …   Wikipedia

  • Primidone — Systematic (IUPAC) name 5 ethyl 5 phenyl hexahydropyrimidine 4,6 dione Clinical data Pregnancy cat. D …   Wikipedia

  • Digoxin — Not to be confused with Dioxin. Digoxin Systematic (IUPAC) name 4 [(3S,5R,8R,9S,10S,12R,13S,14S) 3 [(2S,4S,5R,6R) 5 [(2S,4S,5R,6R) 5 [(2S,4S,5R,6R) 4,5 dihydroxy 6 methyl oxan 2 yl]oxy 4 hydroxy 6 methyl oxan 2 yl …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”