- Therapeutic window
Therapeutic window (or pharmaceutical window) is an
indexfor estimation of drug dosagewhich can treat disease effectively while staying within the safety range. In other words, it is the dosage of a medicationbetween the amount that gives an effect ( effective dose) and the amount that gives more adverse effectsthan desired effects [ [http://www.freepatentsonline.com/20040197415.html freepatentsonline.com] ] . For instance, medication with a small pharmaceutical window such as Tegretol must be administered with care and control, e.g. by frequently measuring blood concentration of the drug, since it easily gives adverse effects such as agranulocytosis[ [https://online.epocrates.com/u/10a1285 Tegretol ] ] .
More specifically, it is the range between the ED50 and the starting point of LD50
curve. It is believed that this index can help to avoid most of the potential side effects. [cite web | title=Therapeutic window@Everything 2 | url= http://www.everything2.com/index.pl?node_id=938353]
This index is believed to be more reliable than that of therapeutic index since this index considers the biological variation among individuals to a larger extent.
= See also =
= Reference =
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