LDL apheresis

LDL apheresis

In medicine, LDL apheresis is a form of apheresis, resembling dialysis, to eliminate the cholesterol-containing particle low-density lipoprotein (LDL) from the bloodstream.

Uses

It is used in diseases featuring high LDL, such as the rare "homozygous" familial hypercholesterolemia, when the "heterozygous" form does not respond to medical treatment, or when the treatment has led to dangerous side-effects (such as rhabdomyolysis).

The procedure takes 2-4 hours and must be repeated every several weeks to keep the LDL levels from accumulation and causing cardiovascular disease.

It is an expensive procedure, limiting its use to severe cases of hyperlipidemia.

Principles

LDL apheresis works by leading venous blood through a collumn coated with antibodies to apolipoprotein B (the main protein of LDL particles), dextran sulfate or polyacrylate, or by precipitating LDL with heparin at low pH. In all cases (apart from polyacrylate absorption), plasma is separated from cells by a cell separator.

References

* Thompson GR. "LDL Apheresis". Atherosclerosis 2003;167:1-13. PMID 12618263.
* Vella A, Pineda AA, O'Brien T. "Low-density lipoprotein apheresis for the treatment of refractory hyperlipidemia." Mayo Clin Proc 2001;76:1039-46. PMID 11605688.

External links

* [http://www.csmc.edu/2350.html LDL apheresis] information on from Cedars-Sinai Medical Centre.

* [http://www.liposorber.com LDL apheresis] information on from Liposorber.


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Apheresis — (Greek: to take away ) is a medical technology in which the blood of a donor or patient is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation. It is thus an extracorporeal… …   Wikipedia

  • LDL-Apherese — Unter dem Begriff LDL Apherese werden extrakorporale Blutreinigungsverfahren zur ambulanten Elimination von LDL Cholesterin aus dem Blutkreislauf des Patienten zusammengefasst. Da die meisten Therapieverfahren neben LDL Cholesterin auch andere… …   Deutsch Wikipedia

  • Lipidapherese — Die Lipidapherese ist ein extrakorporales Blutreinigungsverfahren zur Entfernung von LDL Cholesterin und weiteren Faktoren der Arteriosklerose wie Lipoprotein(a) und Triglyzeriden aus dem Blut. Die Lipidapherese wird bei Patienten eingesetzt, die …   Deutsch Wikipedia

  • Familial hypercholesterolemia — Classification and external resources Xanthelasma palpebrarum, yellowish patches consisting of cholesterol deposits above the eyelids. These are more common in people with FH. ICD …   Wikipedia

  • Lipoprotein a — Apolipoprotein(a) Masse/Länge Primärstruktur 4529 Aminosäuren …   Deutsch Wikipedia

  • Hypercholesterolemia — DiseaseDisorder infobox Name = Hypercholesterolemia Caption = Cholesterol ICD10 = ICD10|E|78|0|e|70 ICD9 = ICD9|272.0 ICDO = OMIM = DiseasesDB = 6226 MedlinePlus = eMedicineSubj = med eMedicineTopic = 1073 MeshID = D006937 Hypercholesterolemia… …   Wikipedia

  • Коновалов, Геннадий Александрович — Коновалов Геннадий Александрович (род. 14 марта 1952, Комсомольск на Волге СССР)  Доктор медицинских наук (1990), профессор (1998), российский учёный медик, научный руководитель, Руководитель Центра диагностики и инновационных медицинских… …   Википедия

  • Gehörsturz — Klassifikation nach ICD 10 H90.3 Hörverlust, Schallempfindungsstörung, beidseitig H90.4 Hörverlust, Schallempfindungsstörung, einseitig H91.2 …   Deutsch Wikipedia

  • Hörsturz — Klassifikation nach ICD 10 H90.3 Hörverlust, Schallempfindungsstörung, beidseitig H90.4 Hörverlust, Schallempfindungsstörung, einseitig …   Deutsch Wikipedia

  • Nadey Hakim — GCSJ, MD, PhD, FRCS, FRCSI, FACS, FICS(Hon), FASMBS, FINS(Hon), FIMSA (Hon), born April 9, 1958. General, transplant and bariatric surgeon. Biography Nadey Hakim [1] is a doctor, surgeon and prolific author. He is Surgical Director West London… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”