Immunophilins

Immunophilins

In molecular biology, immunophilins are peptidyl-prolyl isomerases that intraconvert between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as rapamycin, cyclosporin, and FK-506. For these drugs in particular, known immunophilins such as cyclophilin catalyze the "cis-trans" isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs.

ee also

* Cyclophilin
* FKBP52

External links

*
* [http://pmb.berkeley.edu/faculty/faculty_pages/Luan.html "Plant immunophilins and signal transduction" at berkeley.edu]


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