Hyperhomocysteinemia

Hyperhomocysteinemia

Infobox_Disease
Name = Hyperhomocysteinemia


Caption = Homocysteine
DiseasesDB = 29853
ICD10 =
ICD9 =
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = neuro
eMedicineTopic = 578
MeshID =

Hyperhomocysteinemia is a medical condition characterized by an abnormally large level of homocysteine in the blood.

As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of the vitamins folic acid, pyridoxine (B6), or B12 can lead to high homocysteine levels. cite journal | author=Miller JW, Nadeau MR, Smith D, Selhub J | title=Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats | journal=American Journal of Clinical Nutrition | year=1994 | volume=59 | pages= 1033–1039 | pmid=8172087] Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream. cite journal | author=van Guldener C, Stehouwer CD | title=Homocysteine-lowering treatment: an overview | journal=Expert Opinion on Pharmacotherapy | year=2001 | volume=2 | issue=9 | pages= 1449–1460 | pmid=11585023 | doi=10.1517/14656566.2.9.1449]

Normal fasting homocysteine plasma levels are between 5,0 and 15,9 mmol/l.

ee also

* HomocystinuriaHyperhomocysteinemia is a risk factor for coronary artery disease and in cases of young myocardial infarction the level is found to be elevated.

* Methylenetetrahydrofolate reductaseMTHFR (A1298C) DNA Gene mutation has been associated with an increased risk for Hyperhomocysteinemia. MTHFR is involved in the methylation of homocysteine to methionine. Individuals with MTHFR gene mutations that reduce enzyme activity, may develop hyperhomocysteinemia and thus be at risk for vascular disease. There are holistic treatments.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • hyperhomocysteinemia — noun The presence of an excessive amount of homocysteine in the blood See Also: homocysteinemia …   Wiktionary

  • hyperhomocysteinemia — hy·per·ho·mo·cys·te·in·emia (hi″pər ho″mo sisґte in eґme ə) the presence of excessive homocysteine in the blood, a condition closely related to homocystinuria. Called also homocysteinemia …   Medical dictionary

  • Cystathionine beta synthase — Structure of human cystathionine beta synthase.[1] …   Wikipedia

  • Homocisteinemia — Se denomina homocisteinemia a un grupo de enfermedades metabólicas que se caracterizan por presentar un fenotipo característico, consistente en un nivel elevado del aminoácido homocisteína en plasma. Hasta hace un tiempo, un nivel de homocisteína …   Wikipedia Español

  • Levomefolic acid — IUPAC name (2S) 2 [ [4 [(2 Amino 5 methyl 4 oxo 1,6,7,8 tetrahydropteridin 6 yl) methylamino]benzoyl] …   Wikipedia

  • Folic acid — Folic acid …   Wikipedia

  • Methylenetetrahydrofolate reductase — methylene tetrahydrofolate reductase [NAD(P)H] Ribbon diagram of the active site of E. coli MTHFR. The flavin cofactor (top) is shown interacting with the bound substrate NADH.[1] …   Wikipedia

  • Pro-oxidant — Pro oxidants are chemicals that induce oxidative stress, either through creating reactive oxygen species or inhibiting antioxidant systems. [cite journal |author=Puglia CD, Powell SR |title=Inhibition of cellular antioxidants: a possible… …   Wikipedia

  • 5,10-Methylenetetrahydrofolate reductase — 5,10 Méthylènetétrahydrofolate réductase MTHFR d E.coli. Image provenant de PDB:1ZPT L’enzyme 5,10 Méthylènetétrahydrofolate réductase est nommé MTHFR. C est un homodimère présent dans le …   Wikipédia en Français

  • 5,10-Méthylènetétrahydrofolate réductase — MTHFR d E.coli. Image provenant de PDB:1ZPT Caractéristiques générales Entrez …   Wikipédia en Français

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”