Hyperhomocysteinemia

Hyperhomocysteinemia

Infobox_Disease
Name = Hyperhomocysteinemia


Caption = Homocysteine
DiseasesDB = 29853
ICD10 =
ICD9 =
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = neuro
eMedicineTopic = 578
MeshID =

Hyperhomocysteinemia is a medical condition characterized by an abnormally large level of homocysteine in the blood.

As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of the vitamins folic acid, pyridoxine (B6), or B12 can lead to high homocysteine levels. cite journal | author=Miller JW, Nadeau MR, Smith D, Selhub J | title=Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats | journal=American Journal of Clinical Nutrition | year=1994 | volume=59 | pages= 1033–1039 | pmid=8172087] Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream. cite journal | author=van Guldener C, Stehouwer CD | title=Homocysteine-lowering treatment: an overview | journal=Expert Opinion on Pharmacotherapy | year=2001 | volume=2 | issue=9 | pages= 1449–1460 | pmid=11585023 | doi=10.1517/14656566.2.9.1449]

Normal fasting homocysteine plasma levels are between 5,0 and 15,9 mmol/l.

ee also

* HomocystinuriaHyperhomocysteinemia is a risk factor for coronary artery disease and in cases of young myocardial infarction the level is found to be elevated.

* Methylenetetrahydrofolate reductaseMTHFR (A1298C) DNA Gene mutation has been associated with an increased risk for Hyperhomocysteinemia. MTHFR is involved in the methylation of homocysteine to methionine. Individuals with MTHFR gene mutations that reduce enzyme activity, may develop hyperhomocysteinemia and thus be at risk for vascular disease. There are holistic treatments.

References


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