Tumor metabolome

The term tumor metabolome describes the characteristic metabolic phenotype of tumor cells.

Comparison of the metabolic characteristics of different tumor cell lines and tumors revealed that during tumorigenesis, the same alterations always occur in distinct metabolic parameters regardless of the basic metabolism of the tissues from which the tumor developed, such as brain or liver and regardless of the molecular mechanism by which tumorigenesis was induced.

The characteristic attributes of the tumor metabolome are:
*high glycolytic enzyme activities
*the expression of the pyruvate kinase isoenzyme type M2, which is mainly in its dimeric form (= Tumor M2-PK)
*increased channeling of glucose carbons into synthetic processes, such as nucleic acid, amino acid and phospholipid synthesis
*a high rate of pyrimidine and purine de novo synthesis
*a low (ATP+GTP) : (CTP+UTP) ratio
*low AMP levels
*high glutaminolytic capacities
*release of immunosuppressive substances
*dependency on methionine

References

* cite journal
last = Mazurek
first = S.
coauthors = Grimm H.; Boschek CB; Vaupel P; Eigenbrodt E
title = Pyruvate kinase type M2: a crossroad in the tumor metabolome
journal = The British Journal of Nutrition
month = January
year = 2002
volume = 87
pages = S23–S29
pmid = 11895152
doi = 10.1079/BJN2001455

* cite journal
last = Mazurek
first = S.
coauthors = Eigenbrodt E.
title = The tumor metabolome
journal = Anticancer Research
month = March-April
year = 2003
volume = 23
pages = 1149–1154
pmid = 12820363

External links

* [http://www.metabolic-database.com metabolic database]