Gattermann-Koch reaction

Gattermann-Koch reaction

The Gattermann-Koch reaction, named for the German chemists Ludwig Gattermann and Julius Arnold Koch, [cite journal | author = Gattermann, L.; Koch, J. A. | journal = Ber. | title = Eine Synthese aromatischer Aldehyde | doi = 10.1002/cber.18970300288 | year = 1897 | volume = 30 | pages = 1622] in organic chemistry refers to a Friedel-Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in-situ with Friedel-Crafts catalyst, namely AlCl3 to produce a benzaldehyde-derivative from a benzene-derivative in one step. [cite book | title = Name Reactions: A Collection of Detailed Reaction Mechanisms | author = LI Jie Jack | isbn = 3540402039 | publisher = Springer | edition = 2nd edition | year = 2003 | pages = 157 | url = http://books.google.com/books?id=6mZJ3084ouAC&pg=PA157&lpg=PA157&dq=%22gattermann+koch%22+reaction&source=web&ots=ku9m3vLfrP&sig=OWVDwJZ1wPRnIDhenbcBL9Dr9KI#PPA157,M1 | format = available on Google Books] Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed.

An example would be the conversion of toluene to "p"-tolualdehyde. [OrgSynth | title = "p"-Tolualdehyde | author = G. H. Coleman, David Craig | collvol = 2 | collvolpages = 583 | year = 1943 | prep = cv2p0583]

ee also

* Friedel-Crafts reaction
* Gattermann reaction

References


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  • gattermann-koch reaction — ˈga]d.ə(r)mənˈkȯk , ˈgä], kȯḵ , kōk , käk noun Usage: usually capitalized G&K Etymology: after Ludwig Gattermann died 1920 and J.A. Koch fl1897 German chemists : a synthesis of an aldehyde from an aromatic hydrocarbon, carbon monoxide,… …   Useful english dictionary

  • Reacción de Gattermann-Koch — La Reacción de Gattermann Koch es una reacción orgánica que consiste en una reacción de acilación tipo Friedel Crafts en los que se utilizan monóxido de carbono y ácido clorhídrico para dar como producto benzaldehido (O el derivado… …   Wikipedia Español

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