Hans Kosterlitz

Hans Kosterlitz

Infobox Scientist
name = Hans Kosterlitz
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image_width =150px
caption = Hans Kosterlitz
birth_date = 27 April 1903
birth_place =
death_date = 26 October 1996
death_place =
residence =
citizenship =
nationality = British
ethnicity =
field = Biochemistry
work_institutions =
alma_mater =
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known_for = endorphins
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Hans Walter Kosterlitz (27 April 1903 – 26 October 1996) was a British biologist, who graduated DrMed in Berlin. He settled in Scotland and took a DSc at the University of Aberdeen where he was, for many years, Reader in Physiology.

Kosterlitz is best known for his work on endorphins. He performed a famous experiment that he envisioned in a dream while sleeping. He stimulated a strip of guinea pig intestine electrically and was able to record the contractions with a polygraph. He then found that if you added opiates to the solution, the intestine would not contract. Opiates inhibit intestinal contraction. Those contractions were later found to resume in the presence of both opiates and an antagonist such as naloxone. Later, endogenous endorphins were discovered by applying tissue (mouse brain homegenate) to the apparatus. This caused the contractions to cease. The degree to which an opiate agonist causes contractions in the guinea pig ileum is highly correlated to its potency.

He was elected a Fellow of the Royal Society in 1978.


id = PMID:9673787
url= http://www.ncbi.nlm.nih.gov/pubmed/9673787
first=G M
publication-date=1998 Mar
title=A tribute to the late Hans W. Kosterlitz: ploughing the lone furrow.
periodical=Can. J. Physiol. Pharmacol.

id = PMID:9142421
url= http://www.ncbi.nlm.nih.gov/pubmed/9142421
first2=H W
first3=T W
publication-date=1997 Feb
title=The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977.
issue=4 Suppl
periodical=Br. J. Pharmacol.
pages=428-36; discussion 426-7

id = PMID:9142417
url= http://www.ncbi.nlm.nih.gov/pubmed/9142417
first3=H W
publication-date=1997 Feb
title=A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. 1972.
issue=4 Suppl
periodical=Br. J. Pharmacol.
pages=396-8; discussion 393-5

id = PMID:8945465
url= http://www.ncbi.nlm.nih.gov/pubmed/8945465
publication-date=1996 Dec 5
title=Hans Kosterlitz (1903-96)
doi = 10.1038/384418a0

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