- Hans Kosterlitz
Infobox Scientist
name = Hans Kosterlitz
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caption = Hans Kosterlitz
birth_date =27 April 1903
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death_date =26 October 1996
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nationality = British
ethnicity =
field =Biochemistry
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known_for =endorphin s
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Hans Walter Kosterlitz (27 April 1903 –26 October 1996 ) was a British biologist, who graduated DrMed in Berlin. He settled in Scotland and took a DSc at the University of Aberdeen where he was, for many years, Reader in Physiology.Kosterlitz is best known for his work on
endorphin s. He performed a famous experiment that he envisioned in a dream while sleeping. He stimulated a strip of guinea pig intestine electrically and was able to record the contractions with a polygraph. He then found that if you added opiates to the solution, the intestine would not contract. Opiates inhibit intestinal contraction. Those contractions were later found to resume in the presence of both opiates and an antagonist such as naloxone. Later, endogenous endorphins were discovered by applying tissue (mouse brain homegenate) to the apparatus. This caused the contractions to cease. The degree to which an opiate agonist causes contractions in the guinea pig ileum is highly correlated to its potency.He was elected a Fellow of the
Royal Society in 1978.References
*Citation
id =PMID :9673787
url= http://www.ncbi.nlm.nih.gov/pubmed/9673787
last=Lees
first=G M
publication-date=1998 Mar
year=1998
title=A tribute to the late Hans W. Kosterlitz: ploughing the lone furrow.
volume=76
issue=3
periodical=Can. J. Physiol. Pharmacol.
pages=244-51
*Citation
id =PMID :9142421
url= http://www.ncbi.nlm.nih.gov/pubmed/9142421
last=Hughes
first=J
last2=Kosterlitz
first2=H W
last3=Smith
first3=T W
publication-date=1997 Feb
year=1997
title=The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977.
volume=120
issue=4 Suppl
periodical=Br. J. Pharmacol.
pages=428-36; discussion 426-7
*Citation
id =PMID :9142417
url= http://www.ncbi.nlm.nih.gov/pubmed/9142417
last=Henderson
first=G
last2=Hughes
first2=J
last3=Kosterlitz
first3=H W
publication-date=1997 Feb
year=1997
title=A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. 1972.
volume=120
issue=4 Suppl
periodical=Br. J. Pharmacol.
pages=396-8; discussion 393-5
*Citation
id =PMID :8945465
url= http://www.ncbi.nlm.nih.gov/pubmed/8945465
last=Hughes
first=J
publication-date=1996 Dec 5
year=1996
title=Hans Kosterlitz (1903-96)
volume=384
issue=6608
periodical=Nature
pages=418
doi = 10.1038/384418a0
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