Epoxyeicosatrienoic acid

Epoxyeicosatrienoic acid

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.ref|Spector

Biological effects

EETs are cardioprotective after ischemic heart attack and reperfusion.ref|Nithipatikom They act in the corpus cavernosum to maintain penile erection.ref|Jin Specific epoxidation of EET sites produces endogenous PPARα agonists.ref|Ng

References

# Cite web| author= Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.|work= Am J Physiol Heart Circ Physiol. date=2006 Feb 10|title= Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury.| url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16473964&query_hl=4&itool=pubmed_docsum| accessdate=2006-03-11
# Cite web|work= FASEB J. 2006 Mar;20(3):539-41. |date= 2006 Jan 13. |title= Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.|author= Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC.|accessdate=2006-03-11|url= http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16415108&query_hl=4&itool=pubmed_docsumPubMed cite.
#cite journal
author = Spector AA,Fang X, Snyder GD, Weintraub NL
journal= Prog Lipid Res |year= 2004 |month =Jan
volume= 43| issue=1 |pages=55–90
title= Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function
pmid = 14636671
doi= 10.1016/S0163-7827(03)00049-3
#cite journal
author = Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL
journal = Drug Metab Dispos | year= 2007 |month =Jul
volume= 37 | issue= 7 |pages=1126–1134
title = Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha
pmid = 17431031
doi = 10.1124/dmd.106.013839


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