IUPAC_name = 2-diethylamino-1-phenyl-propan-1-one

CAS_number = 90-84-6
ATC_prefix = A08
ATC_suffix = AA03
PubChem = 7029
DrugBank =
molecular_weight = 205.30
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_category = B
legal_US = Schedule IV
legal_status =
routes_of_administration =

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.


Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the "N,N"-diethyl homologue of cathinone and dimethylcathinone. It has been found to be potentially neurotoxic in that it causes long-term depletions of 5-HT similar to MDMA. [ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301]

Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets ( "Tenuate, Tepanil Ten-Tab"). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).


*Hypersensitivity to sympathomimetic amines
*Advanced arteriosclerosis or symptomatic cardiovascular disease
*Moderate or severe hypertension
*History of drug abuse
*MAO inhibitor use (within 14 days)

ide effects

*Pulmonary hypertension

*Tachycardia, hypertension, arrhythmia, chest pain

;Ear, nose, and throat
*Xerostomia, metallic taste

*Changes in libido, gynecomastia, menstrual irregularities

*Blurred vision

*Nausea/vomiting, constipation, abdominal cramps

*Bone marrow depression, agranulocytosis, leukopenia


*Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

*Rash, hives, alopecia, ecchymosis

;Urogenital and reproductive
*Changes in libido, impotence

ee also

* Methcathinone
* Methylenedioxymethcathinone


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