Local gigantism

Local gigantism

s, where it is termed macrodactyly. However, sometimes an entire limb may be enlarged.

Causes

Local gigantism may be caused by a heterogeneous group of both congenital and acquired conditions.

Congenital

Congenital causes include:
*Klippel Trenaunay Weber syndrome
*Maffucci syndrome
*macrodystrophia lipomatosa [ [http://www.ijri.org/articles/archives/20001002/letter3.htm Letter to the Indian Journal of Radiology and Imaging] ]
*neurofibromatosis, [cite journal |author=Lassmann H, Gebhart W, Mamoli B, Niebauer G |title=Nervous lesions in a case of local gigantism |journal=Acta Neuropathol. |volume=38 |issue=2 |pages=109–15 |year=1977 |pmid=878849 |doi=] [cite journal |author=Chung IH, Kim NH, Choi IY |title=Macrodactylism associated with neurofibroma of the median nerve. A case report |journal=Yonsei Med. J. |volume=14 |issue= |pages=49–52 |year=1973 |pmid=4804132 |doi=]
*lipoatrophic diabetes. [ [http://www.ijri.org/articles/current_issue/gyn_349.asp Some case reports] ]
*Proteus syndrome, which affected the Elephant Man

Acquired

There are a number of acquired causes of local gigantism. A body part can attain bigger size from causes as common as the following:
*inflammation, due to trauma or infection
*tumors like osteoid osteoma, melorheostosis, and lipofibromatous hamartoma [cite journal |author=Razzaghi A, Anastakis DJ |title=Lipofibromatous hamartoma: review of early diagnosis and treatment |journal=Canadian Journal of Surgery. Journal canadien de chirurgie |volume=48 |issue=5 |pages=394–9 |year=2005 |pmid=16248139 |doi=]
*Arteriovenous malformations occurring on a limb, before the closure of epiphyses in long bones [ [http://indianheartjournal.com/SeptOctober2001/abstact/659-662/265_focal_gigantism.htm Case report] ]
*Elephantiasis, which is quite common in south-east asia due to prevalence of filariasis.
*Still's disease
*amyloidosis
*acromegaly

Treatment

As the causes of local gigantism are varied, treatment depends on the particular condition. Treatment may range from antibiotics and other medical therapy, to surgery in order to correct the anatomical anomaly.

References

External links

* [http://www.medcyclopaedia.com/library/topics/volume_iii_1/g/GIGANTISM.aspx Medcyclopedia article]


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • local gigantism — noun A condition in which a certain part of the body acquires larger than normal size due to excessive growth of the anatomical structures or abnormal accumulation of substances …   Wiktionary

  • Gigantism — Classification and external resources Anna Haining Bates with her parents ICD 10 E22.0, E …   Wikipedia

  • Klippel-Trénaunay-Weber syndrome — DiseaseDisorder infobox Name = Klippel Trénaunay Weber Syndrome ICD10 = ICD10|Q|87|2|q|80 (EUROCAT Q87.21) ICD9 = ICD9|759.89 Caption = ICDO = OMIM = 149000 DiseasesDB = 29324 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 213 MeshID =… …   Wikipedia

  • Galápagos tortoise — Conservation status …   Wikipedia

  • human embryology — ▪ biology Introduction       the process encompassing the period from the formation of an embryo, through the development of a fetus, to birth.       The human body, like that of most animals, develops from a single cell produced by the union of… …   Universalium

  • syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… …   Medical dictionary

  • Parthie — Empire parthe Ashkâniân 247 av. J. C. – 224 ap. J. C. Carte de l Empire parthe en 60 av. J. C. Informations générales …   Wikipédia en Français

  • Bao Xishun — in Stockholm 2006 Born 1951 (age 59–60) Inner Mongolia, China Occupation Herdsman …   Wikipedia

  • quaternary — /kwot euhr ner ee, kweuh terr neuh ree/, adj., n., pl. quaternaries. adj. 1. consisting of four. 2. arranged in fours. 3. (cap.) Geol. noting or pertaining to the present period of earth history, forming the latter part of the Cenozoic Era,… …   Universalium

  • drug — drug1 /drug/, n., v., drugged, drugging. n. 1. Pharm. a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well being. 2. (in federal law) a. any substance… …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”