Hitachimycin

Drugbox
IUPAC_name = (2"Z",4"E",6"E",12"E")-16,20-dihydroxy-21-methoxy-
3-methyl-10-phenyl-9-azabicyclo [17.3.0]
docosa-2,4,6,12,19-pentaene-8,18-dione

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CAS_number=77642-19-4
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PubChem=5384563
DrugBank=
C = 29 |H = 35 |N = 1 |O = 5
molecular_weight = 477.592 g/mol
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Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by "Streptomyces" that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis. [cite journal |author=Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I |title=Studies on the biological activity of stubomycin |journal=J. Antibiot. |volume=36 |issue=3 |pages=301–11 |year=1983 |pmid=6833150 |doi=] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic. [cite journal |author=Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M |title=A new antitumor antibiotic, stubomycin |journal=J. Antibiot. |volume=34 |issue=3 |pages=259–65 |year=1981 |pmid=7275806 |doi=]

As of 2007, it has not been used in a clinical setting.

References