MSin3 interaction domain

MSin3 interaction domain

The mSin3 interaction domain (SID) is present on several transcriptional repressor proteins including TGFβ (transforming growth factor β) and Mad. It interacts with the paired amphipathic alpha-helix 2 (PAH2) domain of mSin3, a transcriptional repressor domain attached to some transcription repressor proteins such as the mSin3A corepressor.

Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.

External links

* [http://cgd.aacrjournals.org/cgi/reprint/12/9/457.pdf The Smad Transcriptional Corepressor TGIF Recruits mSin3]
* [http://www.huntsmancancer.org/publicweb/content/ayer/pdfs/8.pdf A 13-Amino Acid Amphipathic α-Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Nuclear receptor co-repressor 1 — Nuclear receptor corepressor 1 Rendering based on PDB 2EQR …   Wikipedia

  • Nuclear receptor co-repressor 2 — Nuclear receptor corepressor 2 PDB rendering based on 1xc5 …   Wikipedia

  • NCOR1 — Correpresor 1 de receptor nuclear HUGO 7672 Símbolo NCOR1 Símbolos alt. KIAA1047; MGC104216; N CoR; TRAC1; hCIT529I10; hN C …   Wikipedia Español

  • RBBP7 — Retinoblastoma binding protein 7, also known as RBBP7, is a human gene. PBB Summary section title = summary text = This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD repeat proteins. It is… …   Wikipedia

  • LRCH4 — Leucine rich repeats and calponin homology (CH) domain containing 4, also known as LRCH4, is a human gene.cite web | title = Entrez Gene: LRCH4 leucine rich repeats and calponin homology (CH) domain containing 4| url =… …   Wikipedia

  • SIN3B — SIN3 homolog B, transcription regulator (yeast), also known as SIN3B, is a human gene.cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView …   Wikipedia

  • MXD1 — Proteína 1 de dimerización MAX Estructura tridimensional de la proteína MXD1. HUGO 6 …   Wikipedia Español

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”