Stringent response

Stringent response

The stringent response occurs in all prokaryotes and some plants in reaction to amino-acid starvation or carbon starvation. The stringent response is capable of modulating up to 1/3 of all genes in a cell. It causes the cell to divert resources away from growth and division and toward amino acid synthesis.

(p)ppGpp production is mediated by the ribosome parts: RelA and L11A when there are no charged tRNA's available to bind to the ribosome. RelA converts GTP and ATP into pppGpp by adding the pyrophosphate from ATP onto the 3' carbon of the ribose in GTP releasing AMP.

pppGpp is converted to ppGpp by the "gpp" gene product, releasing Pi.ppGpp is converted to GDP by the spoT gene product, releasing pyrophosphate (PPi).GDP is converted to GTP by the ndk gene product. NTP provides the Pi, and is converted to NDP.

The cycle repeats when GTP is reacted with ATP by the RelA gene.

(p)ppGpp inhibits other energy-consuming cell process, such as replication and transcription.

Chemical Reaction:

ATP ----> AMP

GTP ----> pppGpp


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • stringent response — stringent response. См. строгий ответ. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Stringent Response — Die Stringent Response (Deutsch manchmal auch „stringente Antwort“) ist eine Anpassung des Stoffwechsels von Prokaryoten auf eine Unterversorgung mit Nährstoffen wie Kohlenstoff oder Aminosäuren. Sie äußert sich durch eine erhöhte Stressresistenz …   Deutsch Wikipedia

  • Stringent response — Die Stringent Response (Deutsch manchmal auch „stringente Antwort“) ist eine Anpassung des Stoffwechsels von Prokaryoten auf eine Unterversorgung mit Nährstoffen wie Kohlenstoff oder Aminosäuren. Sie äußert sich durch eine erhöhte Stressresistenz …   Deutsch Wikipedia

  • stringent — strin‧gent [ˈstrɪndʒənt] adjective 1. stringent rule/​control/​test a rule, control etc that is very strict and must be obeyed: • Stringent air quality standards will be imposed on oil companies. 2. ECONOMICS stringent economic conditions exist… …   Financial and business terms

  • response — 1. The reaction of a muscle, nerve, gland, or other excitable tissue to a stimulus. 2. Any act or behavior, or its constituents, that a living organism is capable of emitting. Reflexes are usually excluded because they are typically elicited by a …   Medical dictionary

  • строгий ответ — stringent response строгий ответ. Реакция бактериальной клетки на голодание по аминокислотам, проявляющаяся в резком снижении синтеза тРНК и рРНК (в 10 20 раз), образования рибосом и т.п.; медиатором С.о. является гуанозинтетрафосфат… …   Молекулярная биология и генетика. Толковый словарь.

  • Guanosin-3',5'-bispyrophosphat — Strukturformel Allgemeines Name Guanosin 3 ,5 bispyrophosphat Andere Namen ppGpp Guanosin 5 ,3 tetraphosphat …   Deutsch Wikipedia

  • PpGpp — Strukturformel Allgemeines Name Guanosin 3 ,5 bispyrophosphat Andere Namen ppGpp Guanosin 5 ,3 tetraphosphat …   Deutsch Wikipedia

  • Guanosin-3′,5′-bispyrophosphat — Strukturformel Allgemeines Name Guanosin 3′,5′ bispyrophosphat Andere Namen …   Deutsch Wikipedia

  • factor — 1. One of the contributing causes in any action. 2. One of the components that by multiplication makes up a number or expression. 3. SYN: gene. 4. A vitamin or other essential element. 5. An event, characteristic, or other definable entity that …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”