Time delay toxin activation

Time delay toxin activation

Time Delay Toxin Activation (TDTA) belongs to a class of chemotherapy drugs known as High Specificity Anticancer Agents. This is a process for manufacturing and administering chemotherapy drugs in a nontoxic, proto-drug form. Then, after a time delay to allow for concentration in the target cancer or invasive tissues or cells, the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active agent to the target issue. This minimizes the toxicity to healthy cells, reducing the adverse side-effects of chemotherapy.

This idea was first proposed by Dr. Evan Harris Walker in 1980.


* cite web
title = US Patent Office application number 20040192578
accessdate = February 02
accessyear = 2006

* cite web
title=High specificity anticancer agents
work=USPTO Full text patent database
accessdate=January 29

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