TCF21

TCF21

TCF21 is a tumor suppressor gene which regulates mesenchymal cell transition into epithelial cells. It is frequently lost in human malignancies and is expressed in normal lung airway epithelial cells. It is silenced in the majority of head and neck squamous cell carcinomas and non-small-cell lung cancer tumor cells through a chemical change known as DNA methylation, a process that is potentially reversible.

The gene is located on chromosome 6, in region 6q23-q24.

References

*
* [http://researchnews.osu.edu/archive/lungcagn.htm Ohio State University press release]
* [http://www.sciencedaily.com/releases/2006/01/060119233405.htm Science Daily article]


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  • TCF21 (gene) — Transcription factor 21, also known as TCF21, is a human gene.cite web | title = Entrez Gene: TCF21 transcription factor 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6943| accessdate = ] PBB Summary… …   Wikipedia

  • Tumor suppressor gene — A tumor suppressor gene, or antioncogene is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with… …   Wikipedia

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