- Impossible syndrome
Impossible Syndrome, or Chondrodysplasia situs inversus imperforate anus polydactyly, is a complex combination of human congenital malformations (birth defects)cite journal |author=Fraser FC, Jequier S, Chen MF |title=Chondrodysplasia, situs inversus totalis, cleft epiglottis and larynx, hexadactyly of hands and feet, pancreatic cystic dysplasia, renal dysplasia/absence, micropenis and ambiguous genitalia, imperforate anus |journal=Am J Med Genet. |volume=34 |issue=3 |pages=401–405 |year=1989 |pmid=2596528 |doi=10.1002/ajmg.1320340316 ] .
The malformations include
chondrodysplasia(improper growth of bone and cartilage), situs inversus totalis (chest and abdominal organs all a mirror imageof normal), cleft epiglottisand larynx, hexadactyly (six digits) on hands and feet, diaphragmatic hernia, pancreatic abnormalities, kidneyabnormal on one side and absent on the other side, micropenisand ambiguous genitalia, and imperforate anus.
The inheritance of Impossible syndrome is suspected to be
autosomal recessive, which means the affected gene is located on an autosome, and two copies of the gene - one from each parent - are required to have an infant with the disorder.
* [http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=1424 Overview] at
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