GRB7

Growth factor receptor-bound protein 7, also known as GRB7, is a human gene.cite web | title = Entrez Gene: GRB7 growth factor receptor-bound protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886| accessdate = ] PBB_Summary
section_title =
summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.cite web | title = Entrez Gene: GRB7 growth factor receptor-bound protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886| accessdate = ] GRB7 is an SH2-domain adaptor protein that binds to Receptor-tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene.Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias her2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in breast cancers.
GRB7, thought to be involved in migration Fact|date=September 2007, is well known to be over-expressed in testicular germ cell tumors, esophagous cancers, and gastric cancers.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Han DC, Shen TL, Guan JL |title=The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. |journal=Oncogene |volume=20 |issue= 44 |pages= 6315–21 |year= 2001 |pmid= 11607834 |doi= 10.1038/sj.onc.1204775
*cite journal | author=Margolis B, Silvennoinen O, Comoglio F, "et al." |title=High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 8894–8 |year= 1992 |pmid= 1409582 |doi=
*cite journal | author=Skotheim RI, Abeler VM, Nesland JM, "et al." |title=Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. |journal=Neoplasia. |volume=5 |issue= 5 |pages= 397-404 |year= 2003 |pmid= 14670177 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Pandey A, Liu X, Dixon JE, "et al." |title=Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10607–10 |year= 1996 |pmid= 8631863 |doi=
*cite journal | author=Yokote K, Margolis B, Heldin CH, Claesson-Welsh L |title=Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30942–9 |year= 1997 |pmid= 8940081 |doi=
*cite journal | author=Tanaka S, Mori M, Akiyoshi T, "et al." |title=Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. |journal=Cancer Res. |volume=57 |issue= 1 |pages= 28–31 |year= 1997 |pmid= 8988034 |doi=
*cite journal | author=Janes PW, Lackmann M, Church WB, "et al." |title=Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8490–7 |year= 1997 |pmid= 9079677 |doi=
*cite journal | author=Kishi T, Sasaki H, Akiyama N, "et al." |title=Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 5–9 |year= 1997 |pmid= 9125150 |doi= 10.1006/bbrc.1997.6218
*cite journal | author=Dong LQ, Du H, Porter SG, "et al." |title=Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29104–12 |year= 1997 |pmid= 9360986 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Fiddes RJ, Campbell DH, Janes PW, "et al." |title=Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7717–24 |year= 1998 |pmid= 9516479 |doi=
*cite journal | author=Tanaka S, Mori M, Akiyoshi T, "et al." |title=A novel variant of human Grb7 is associated with invasive esophageal carcinoma. |journal=J. Clin. Invest. |volume=102 |issue= 4 |pages= 821–7 |year= 1998 |pmid= 9710451 |doi=
*cite journal | author=Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L |title=Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor. |journal=Biochem. J. |volume=341 ( Pt 1) |issue= |pages= 211–6 |year= 1999 |pmid= 10377264 |doi=
*cite journal | author=Han DC, Guan JL |title=Association of focal adhesion kinase with Grb7 and its role in cell migration. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24425–30 |year= 1999 |pmid= 10446223 |doi=
*cite journal | author=Jones N, Master Z, Jones J, "et al." |title=Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30896–905 |year= 1999 |pmid= 10521483 |doi=
*cite journal | author=Vayssière B, Zalcman G, Mahé Y, "et al." |title=Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 91–6 |year= 2000 |pmid= 10664463 |doi=
*cite journal | author=Kasus-Jacobi A, Béréziat V, Perdereau D, "et al." |title=Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. |journal=Oncogene |volume=19 |issue= 16 |pages= 2052–9 |year= 2000 |pmid= 10803466 |doi= 10.1038/sj.onc.1203469
*cite journal | author=Han DC, Shen TL, Guan JL |title=Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28911–7 |year= 2000 |pmid= 10893408 |doi= 10.1074/jbc.M001997200
*cite journal | author=Lee H, Volonte D, Galbiati F, "et al." |title=Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1750–75 |year= 2001 |pmid= 11075810 |doi=
*cite journal | author=Skotheim RI, Abeler VM, Nesland JM, "et al." |title=Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. |journal=Neoplasia. |volume=5 |issue= 5 |pages= 397-404 |year= 2003 |pmid= 14670177 |doi=

External links

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