Ancestry-informative marker
- Ancestry-informative marker
. Other collections of AIMs have been developed that can estimate the geographical origins of ancestors from within Europe.[Bauchet M, McEvoy B, Pearson L, Quillen E, Sarkisian T, Hovhannesyan K, Deka R, Bradley D, Shriver M. 2007. "Measuring European population stratification with microarray genotype data. American Journal of Human Genetics" 80(5): 948-956.doi|10.1086/513477] This has been developed into a commercial package. [ [http://www.dna-worldwide.com/ancestry-testing/general-ancestry/euro-dna-20/ Euro DNA 2.0] ] ]Charles Rotimi, of Howard University's National Human Genome Center, is among those who have highlighted the methodological flaws in such research — that "the nature or appearance of genetic clustering (grouping) of people is a function of how populations are sampled, of how criteria for boundaries between clusters are set, and of the level of resolution used" all bias the results — and concluded that people should be very cautious about relating genetic lineages or clusters to their own sense of identity. [Charles Rotimi (2003) "Genetic Ancestry Tracing and the Abridan identity: A Double-Edged Sword?" in "Developing World Bioethics" 3(2): 153-154.] (see also How much are genes shared? Clustering analyses and what they tell us)
The company DNAPrint Genomics sells a kit for police to use to identify the ancestry of criminals based on DNA samples from them.
References
*Shriver, Mark D. et al., "Skin pigmentation, biogeographical ancestry and admixture mapping," Hum. Genet. 112, 387-399 (2003) [http://backintyme.com/admixture/shriver01.pdf]
*SNP Science Primer [http://www.ncbi.nlm.nih.gov/About/primer/snps.html]
*dbSNP Summary [http://www.ncbi.nlm.nih.gov/SNP/snp_summary.cgi]
* [http://www.dnaprint.com/welcome/science/ Explanation] from DNAPrint Genomics
ee also
*SLC24A5
*
*How much are genes shared? Clustering analyses and what they tell us
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