AMACR

AMACR

Alpha-methylacyl-CoA racemase, also known as AMACR, is a human gene.cite web | title = Entrez Gene: AMACR alpha-methylacyl-CoA racemase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23600| accessdate = ]

The AMACR protein helps to metabolize certain fatty acids within the body. Several studies have suggested that AMACR can be used as a prostate cancer biomarker [Rubin MA, Bismar TA, Andren O, et al. Decreased {alpha}-methylacyl CoA racemase expression in localized prostate cancer is associated with an increased rate of biochemical recurrence and cancer-specific death. Cancer Epidemiol Biomarkers Prev 2005;14:1424–32] .

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References

Further reading

PBB_Further_reading
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*cite journal | author=Jiang Z, Woda BA, Wu CL, Yang XJ |title=Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S). |journal=Am. J. Clin. Pathol. |volume=122 |issue= 2 |pages= 275–89 |year= 2004 |pmid= 15323145 |doi= 10.1309/EJUY-UQPE-X1MG-68MK
*cite journal | author=Bautch S |title=Wisconsin doctor selected as national symbol of physicians' sacrifices. |journal=Wis. Med. J. |volume=90 |issue= 8 |pages= 485–7 |year= 1991 |pmid= 1926890 |doi=
*cite journal | author=Schmitz W, Albers C, Fingerhut R, Conzelmann E |title=Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. |journal=Eur. J. Biochem. |volume=231 |issue= 3 |pages= 815–22 |year= 1995 |pmid= 7649182 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Schmitz W, Helander HM, Hiltunen JK, Conzelmann E |title=Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. |journal=Biochem. J. |volume=326 ( Pt 3) |issue= |pages= 883–9 |year= 1997 |pmid= 9307041 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ferdinandusse S, Denis S, Clayton PT, "et al." |title=Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 188–91 |year= 2000 |pmid= 10655068 |doi= 10.1038/72861
*cite journal | author=Kotti TJ, Savolainen K, Helander HM, "et al." |title=In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20887–95 |year= 2000 |pmid= 10770938 |doi= 10.1074/jbc.M002067200
*cite journal | author=Amery L, Fransen M, De Nys K, "et al." |title=Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. |journal=J. Lipid Res. |volume=41 |issue= 11 |pages= 1752–9 |year= 2001 |pmid= 11060344 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Rubin MA, Zhou M, Dhanasekaran SM, "et al." |title=alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. |journal=JAMA |volume=287 |issue= 13 |pages= 1662–70 |year= 2002 |pmid= 11926890 |doi=
*cite journal | author=Luo J, Zha S, Gage WR, "et al." |title=Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. |journal=Cancer Res. |volume=62 |issue= 8 |pages= 2220–6 |year= 2002 |pmid= 11956072 |doi=
*cite journal | author=Zhou M, Chinnaiyan AM, Kleer CG, "et al." |title=Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. |journal=Am. J. Surg. Pathol. |volume=26 |issue= 7 |pages= 926–31 |year= 2002 |pmid= 12131161 |doi=
*cite journal | author=Kuefer R, Varambally S, Zhou M, "et al." |title=alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation. |journal=Am. J. Pathol. |volume=161 |issue= 3 |pages= 841–8 |year= 2002 |pmid= 12213712 |doi=
*cite journal | author=Varambally S, Dhanasekaran SM, Zhou M, "et al." |title=The polycomb group protein EZH2 is involved in progression of prostate cancer. |journal=Nature |volume=419 |issue= 6907 |pages= 624–9 |year= 2002 |pmid= 12374981 |doi= 10.1038/nature01075
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leav I, McNeal JE, Ho SM, Jiang Z |title=Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. |journal=Hum. Pathol. |volume=34 |issue= 3 |pages= 228–33 |year= 2003 |pmid= 12673556 |doi= 10.1053/hupa.2003.42
*cite journal | author=Shen-Ong GL, Feng Y, Troyer DA |title=Expression profiling identifies a novel alpha-methylacyl-CoA racemase exon with fumarate hydratase homology. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3296–301 |year= 2003 |pmid= 12810662 |doi=
*cite journal | author=Zha S, Ferdinandusse S, Denis S, "et al." |title=Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer. |journal=Cancer Res. |volume=63 |issue= 21 |pages= 7365–76 |year= 2004 |pmid= 14612535 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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