TP73L

Tumor protein p73-like, also known as TP73L and p63, is a human gene. It is associated with ectrodactyly-ectodermal dysplasia-cleft syndrome and Hay-Wells syndrome.

Diagnostic utility

p63 immunostaining has utility for differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue; [cite journal |author=Shiran MS, Tan GC, Sabariah AR, Rampal L, Phang KS |title=p63 as a complimentary basal cell specific marker to high molecular weight-cytokeratin in distinguishing prostatic carcinoma from benign prostatic lesions |journal=Med. J. Malaysia |volume=62 |issue=1 |pages=36–9 |year=2007 |month=March |pmid=17682568 |doi= |url=] normal prostatic glands stain with p63 (as they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not. [cite journal |author=Herawi M, Epstein JI |title=Immunohistochemical antibody cocktail staining (p63/HMWCK/AMACR) of ductal adenocarcinoma and Gleason pattern 4 cribriform and noncribriform acinar adenocarcinomas of the prostate |journal=Am. J. Surg. Pathol. |volume=31 |issue=6 |pages=889–94 |year=2007 |month=June |pmid=17527076 |doi=10.1097/01.pas.0000213447.16526.7f |url=]

ee also

*AMACR - another marker for prostate adenocarcinoma

References

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Further reading

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*cite journal | author=Little NA, Jochemsen AG |title=p63. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 1 |pages= 6–9 |year= 2002 |pmid= 11733180 |doi=
*cite journal | author=van Bokhoven H, McKeon F |title=Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. |journal=Trends in molecular medicine |volume=8 |issue= 3 |pages= 133–9 |year= 2002 |pmid= 11879774 |doi=
*cite journal | author=van Bokhoven H, Brunner HG |title=Splitting p63. |journal=Am. J. Hum. Genet. |volume=71 |issue= 1 |pages= 1–13 |year= 2002 |pmid= 12037717 |doi=
*cite journal | author=Brunner HG, Hamel BC, Bokhoven Hv H |title=P63 gene mutations and human developmental syndromes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 284–90 |year= 2003 |pmid= 12357472 |doi= 10.1002/ajmg.10778
*cite journal | author=Jacobs WB, Walsh GS, Miller FD |title=Neuronal survival and p73/p63/p53: a family affair. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 5 |pages= 443–55 |year= 2005 |pmid= 15359011 |doi= 10.1177/1073858404263456
*cite journal | author=Zusman I |title=The soluble p51 protein in cancer diagnosis, prevention and therapy. |journal=In Vivo |volume=19 |issue= 3 |pages= 591–8 |year= 2005 |pmid= 15875781 |doi=
*cite journal | author=Morasso MI, Radoja N |title=Dlx genes, p63, and ectodermal dysplasias. |journal=Birth Defects Res. C Embryo Today |volume=75 |issue= 3 |pages= 163–71 |year= 2005 |pmid= 16187309 |doi= 10.1002/bdrc.20047
*cite journal | author=Barbieri CE, Pietenpol JA |title=p63 and epithelial biology. |journal=Exp. Cell Res. |volume=312 |issue= 6 |pages= 695–706 |year= 2006 |pmid= 16406339 |doi= 10.1016/j.yexcr.2005.11.028

External links

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