- Regulatory sequence
A regulatory sequence (also called a "regulatory region" or a "regulatory area") is a segment of
DNA where regulatory proteins such astranscription factor s bind preferentially. These regulatory proteins bind to short stretches of DNA called regulatory regions, which are appropriately positioned in the genome, usually a short distance 'upstream' of the gene being regulated. By doing so, these regulatory proteins can either recruit another protein complex, called theRNA polymerase . In this way, they controlgene expression and thusprotein expression.Regulatory sequences can also be found in
messenger RNA , but they are generally not as well studied as those in DNA.Fact|date=February 2008 They may be bound byRNA-binding protein s or RNAs (egmiRNA s)Research to find all regulatory regions in the genomes of all sorts of organisms is under way.Fact|date=February 2008
Examples
*
CAAT box
*CCAAT box
*Operator (biology)
*Pribnow box
*TATA box
*SECIS element , mRNA
*Polyadenylation signals, mRNA
*A-box
*Z-box
*C-box
*E-box
*G-box For the insulin gene
Regulatory sequences for the
insulin gene are: [Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription]
*A5
*Z
*negative regulatory element (NRE) [ [http://linkinghub.elsevier.com/retrieve/pii/S0006291X06025575 Biochemical and Biophysical Research Communications ...] ]
*C2
*E2
*A3
*cAMP response element
*A2
*CAAT enhancer binding (CEB)
*C1
*E1
*G1ee also
*
Regulation of gene expression
*Cis-acting element
*Gene regulatory network
*Operon
*Promoter
*Trans-acting factor
*ORegAnno References
External links
* [http://www.oreganno.org ORegAnno - Open Regulatory Annotation Database]
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