Acquired pure red cell aplasia

Acquired pure red cell aplasia

Acquired pure red cell aplasia (or PRCA) refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells.

Causes

Pure red cell aplasia is regarded as an autoimmune disease. It may also be a manifestation of thymoma. It may also be as a result of viral infections such as HIV, herpes, parvovirus B19 (Fifth disease), or hepatitis. Association of pure red cell aplasia with T large granular lymphocyte leukemia is also well recognized, especially in China. [cite journal |author=Kwong YL, Wong KF |title=Association of pure red cell aplasia with T large granular lymphocyte leukaemia |journal=J. Clin. Pathol. |volume=51 |issue=9 |pages=672–5 |year=1998 |pmid=9930071 |pmc=500904 |doi= |url=http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=9930071] Many cases of PRCA are considered idiopathic in that there is no discernible cause detected.

It can be associated with the administration of erythropoietin.cite journal |author=Bennett CL, Luminari S, Nissenson AR, "et al" |title=Pure red-cell aplasia and epoetin therapy |journal=N. Engl. J. Med. |volume=351 |issue=14 |pages=1403–8 |year=2004 |pmid=15459301 |doi=10.1056/NEJMoa040528 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=15459301&promo=ONFLNS19]

Treatment

PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as ciclosporin. It has also been shown to respond to treatments with Rituxan.

ee also

* Diamond-Blackfan anemia (genetic red cell aplasia)
* aplastic anemia (aplasia affecting other bone marrow cells as well)

References

External links

* [http://www.aamds.org Aplastic Anemia & MDS International Foundation]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Pure red cell aplasia — Classification and external resources ICD 10 D60 ICD 9 284.8 …   Wikipedia

  • Aplasia — (Greek: a not; plésein to form) is defective development resulting in the absence of all or part of an organ.Examples*Aplastic anemia *Acquired pure red cell aplasia *Thymic aplasiaee also*Atrophy *Hyperplasia *Hypoplasia *Neoplasia …   Wikipedia

  • Erworbene isolierte aplastische Anämie — Pure Red Cell Aplasia (engl.: Aplasie der roten Blutkörperchen, PRCA) oder isolierte aplastische Anämie bzw. Erythroblastopenie ist eine Anämie, die durch die Zerstörung oder fehlende Neubildung der Erythroblasten im Knochenmark entsteht. Sie… …   Deutsch Wikipedia

  • Aplastic anemia — ICDO = Caption = OMIM = 609135 OMIM mult = MedlinePlus = eMedicineSubj = med eMedicineTopic = 162 DiseasesDB = 866 MeshID = D000741 Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells.… …   Wikipedia

  • Spin (House) — House (TV series) episode episode name = Spin episode no = HOU 206 airdate = November 15, 2005 writer = Sara Hess director = Fred Gerber guest star = Sela Ward as Stacy Warner Currie Graham as Mark Warner Kristoffer Polaha as Jeff season = 2… …   Wikipedia

  • Hematologic disease — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D006402 Hematologic diseases are disorders which primarily affect the blood.Classification of hematologic… …   Wikipedia

  • Erythroblastopenia — (a decrease of red blood cells in a complete blood count) can refer to: * Acquired pure red cell aplasia * Transient erythroblastopenia of childhoodee also* Polycythemia * Anemia …   Wikipedia

  • PRCA — may refer to: *Professional Rodeo Cowboys Association *Protestant Reformed Churches in America *Acquired pure red cell aplasia *Pusch Ridge Christian Academy, a school in Oro Valley, Arizona …   Wikipedia

  • D60 — or D 60 may refer to: D60 steam locomotive, a 1951 Japanese 2 8 4 Berkshire wheel arrangement steam locomotives model Canon EOS D60 Nikon D60 TDK D60, an audio tape with 60 minutes length in each side D60 road (Croatia), a state road and also: D… …   Wikipedia

  • CAPRCA — chronic, acquired, pure red cell aplasia …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”