Binswanger's disease

Binswanger's disease

Infobox_Disease
Name = Binswangers disease


Caption =
DiseasesDB = 1405
ICD10 = ICD10|I|67|3|i|60
ICD9 = ICD9|290.12
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D015140

Binswanger's disease or Subcortical Leukoencephalopathy is a rare form of multi-infarct dementia caused by damage to white brain matter.cite journal |author=Akiguchi I, Tomimoto H, Suenaga T, Wakita H, Budka H |title=Alterations in glia and axons in the brains of Binswanger's disease patients |journal=Stroke |volume=28 |issue=7 |pages=1423–9 |year=1997 |pmid=9227695 |doi= |url=http://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=9227695] It is characterized by loss of memory and intellectual function and by changes in mood.

It was described by Otto Binswanger in 1894.cite journal |author=Pantoni L, Moretti M, Inzitari D |title=The first Italian report on "Binswanger's disease" |journal=Ital J Neurol Sci |volume=17 |issue=5 |pages=367–70 |year=1996 |pmid=8933231|doi=10.1007/BF01999900] Alois Alzheimer first used the phrase "Binswanger's disease" in 1902.cite web |url=http://findarticles.com/p/articles/mi_m2459/is_n1_v23/ai_14904670 |title=Review: Binswanger's disease, leukoaraiosis and dementia | Age and Ageing | Find Articles at BNET.com |accessdate=2008-01-30 |format= |work=]

It was more formally described by Olszewski in 1962.cite journal |author=Loeb C |title=Binswanger's disease is not a single entity |journal=Neurol. Sci. |volume=21 |issue=6 |pages=343–8 |year=2000 |pmid=11441570 |doi= 10.1007/s100720070048|url=http://link.springer-ny.com/link/service/journals/10072/bibs/0021006/00210343.htm] cite journal |author=Olszewski J |title=Subcortical arteriosclerotic encephalopathy. Review of the literature on the so-called Binswanger's disease and presentation of two cases |journal=World Neurol |volume=3 |issue= |pages=359–75 |year=1962 |pmid=14481961 |doi=]

The term is sometimes considered too imprecise for formal nosology.cite journal |author=Pantoni L, Garcia JH |title=The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review |journal=Stroke |volume=26 |issue=7 |pages=1293–301 |year=1995 |pmid=7604429 |doi= |url=http://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=7604429]

Presentation

Binswanger's disease is one of the neurological syndromes associated with hypertension. It is uncommon, but obviously devastating. The histologic findings are diffuse, irregular loss of axons and myelin accompanied by widespread gliosis. Small infarcts may be seen in the frontal lobes. The pathologic mechanism may be damage caused by severe atherosclerosis.

A patient with long term severe hypertension develops progressive dementia. CT scans of the head demonstrate a diffuse loss of deep hemispheric white matter.

Prognosis

Binswanger's disease has no known treatment, let alone cure, although drugs used to treat high blood pressure, depression, arrhythmia and low blood pressure are used to treat the condition's symptoms. [NINDS|binswangers]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Binswanger — is a surname and may refer to:*Harry Binswanger (1944 ), American philosopher. *Ludwig Binswanger (1881 1966), Swiss psychologist, nephew of Otto Binswanger, important in existential psychology. *Otto Ludwig Binswanger (1852 1929), Swiss… …   Wikipedia

  • Binswanger disease — A form of dementia with blood vessel abnormalities in the deep white matter of the brain causing loss of memory, decreasing cognition, and mood changes. Patients usually show signs of abnormal blood pressure (too high or too low), stroke, blood… …   Medical dictionary

  • Disease, Binswanger — A form of dementia with blood vessel abnormalities in the deep white matter of the brain causing loss of memory, decreasing cognition, and mood changes. Patients usually show signs of abnormal blood pressure (too high or too low), stroke, blood… …   Medical dictionary

  • Binswanger disease (dementia encephalitis) — Bins·wang·er disease (dementia, encephalitis) (binґswahng ər) [Otto Binswanger, German neurologist, 1852–1929] see under disease …   Medical dictionary

  • Disease — Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the… …   Medical dictionary

  • Binswanger — Otto Ludwig, German neurologist, 1852–1929. See B. disease, B. encephalopathy …   Medical dictionary

  • Binswanger dementia — see under disease …   Medical dictionary

  • Binswanger encephalitis — see under disease …   Medical dictionary

  • Cerebrovascular disease — Classification and external resources Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels supplying the brain. Hypertension is the most important cause; it damages the blood vessel lining, endothelium …   Wikipedia

  • Moyamoya disease — Moyamoya syndrome Classification and external resources Schematic representation of the circle of Willis, arteries of the brain and brain stem. ICD 10 I …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”