TRAIL

TRAIL

TNF-related apoptosis-inducing ligand (TRAIL), in the field of cell biology, is a ligand molecule which induces the process of cell death called apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.

In humans, the gene that encodes for TRAIL is located at chromosome 3q26.

TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent.

TRAIL has also been designated CD253 (cluster of differentiation 253).

Further reading

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citations =
*cite journal | author=Almasan A, Ashkenazi A |title=Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. |journal=Cytokine Growth Factor Rev. |volume=14 |issue= 3-4 |pages= 337–48 |year= 2004 |pmid= 12787570 |doi=
*cite journal | author=Cha SS, Song YL, Oh BH |title=Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex. |journal=Vitam. Horm. |volume=67 |issue= |pages= 1–17 |year= 2004 |pmid= 15110168 |doi= 10.1016/S0083-6729(04)67001-4
*cite journal | author=Song C, Jin B |title=TRAIL (CD253), a new member of the TNF superfamily. |journal=J. Biol. Regul. Homeost. Agents |volume=19 |issue= 1-2 |pages= 73–7 |year= 2005 |pmid= 16178278 |doi=
*cite journal | author=Bucur O, Ray S, Bucur MC, Almasan A |title=APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy. |journal=Front. Biosci. |volume=11 |issue= |pages= 1549–68 |year= 2006 |pmid= 16368536 |doi=

External links

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  • Trail — Trail, n. 1. A track left by man or beast; a track followed by the hunter; a scent on the ground by the animal pursued; as, a deer trail. [1913 Webster] They traveled in the bed of the brook, leaving no dangerous trail. Cooper. [1913 Webster] How …   The Collaborative International Dictionary of English

  • Trail — steht für: einen schmalen Weg, siehe Trampelpfad einen schmalen Pfad im Mountainbike Sport, siehe Singletrail Laufen abseits befestigter Straßen, siehe Traillauf, eine Disziplin im Reitsport, siehe Westernreiten ein Plattenlabel, siehe Trail… …   Deutsch Wikipedia

  • Trail — (tr[=a]l), v. t. [imp. & p. p. {Trailed}; p. pr. & vb. n. {Trailing}.] [OE. trailen, OF. trailler to trail a deer, or hunt him upon a cold scent, also, to hunt or pursue him with a limehound, F. trailler to trail a fishing line; probably from a… …   The Collaborative International Dictionary of English

  • trail — [ trɛ(j)l ] n. m. • v. 1985; de l angl. trail bike (1969) « moto de motocross », de trail « piste, sentier » ♦ Anglic. Moto légère, polyvalente, dotée de suspensions à grand débattement. Des trails. ● trail nom masculin (anglais trail, piste)… …   Encyclopédie Universelle

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  • Trail — Trail, v. i. 1. To be drawn out in length; to follow after. [1913 Webster] When his brother saw the red blood trail. Spenser. [1913 Webster] 2. To grow to great length, especially when slender and creeping upon the ground, as a plant; to run or… …   The Collaborative International Dictionary of English

  • Trail — Trail, MN U.S. city in Minnesota Population (2000): 62 Housing Units (2000): 35 Land area (2000): 0.992799 sq. miles (2.571337 sq. km) Water area (2000): 0.000000 sq. miles (0.000000 sq. km) Total area (2000): 0.992799 sq. miles (2.571337 sq. km) …   StarDict's U.S. Gazetteer Places

  • Trail, MN — U.S. city in Minnesota Population (2000): 62 Housing Units (2000): 35 Land area (2000): 0.992799 sq. miles (2.571337 sq. km) Water area (2000): 0.000000 sq. miles (0.000000 sq. km) Total area (2000): 0.992799 sq. miles (2.571337 sq. km) FIPS code …   StarDict's U.S. Gazetteer Places

  • trail — [trāl] vt. [ME trailen < MFr trailler < VL * tragulare < L tragula, small sledge, dragnet < trahere, to DRAW] 1. a) to drag or let drag behind one, esp. on the ground, etc. b) to bring along behind [trailing exhaust fumes] c) to pull… …   English World dictionary

  • trail — [n] path, track aisle, beaten track*, byway, footpath, footprints, footsteps, groove*, mark, marks, pathway, road, route, rut, scent, spoor, stream, stroll, tail, trace, train, wake, way; concept 501 trail [v] lag behind, follow bedog, bring up… …   New thesaurus

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