Monopolin

Monopolin
Monopolin complex subunit CSM1
Identifiers
Organism S. cerevisiae
Symbol CSM1
Entrez 850447
RefSeq (mRNA) NM_001178792
RefSeq (Prot) NP_010009
UniProt P25651
Other data
Chromosome III: 0.26 - 0.26 Mb
Casein kinase I homolog HRR25
Identifiers
Organism S. cerevisiae
Symbol HRR25
Entrez 855897
RefSeq (mRNA) NM_001184018
RefSeq (Prot) NP_015120
UniProt P29295
Other data
EC number 2.7.11.1
Chromosome XVI: 0.16 - 0.17 Mb
Monopolin complex subunit LRS4
Identifiers
Organism S. cerevisiae
Symbol LRS4
Entrez 852049
RefSeq (mRNA) NM_001180747
RefSeq (Prot) NP_010727
UniProt Q04087
Other data
Chromosome IV: 1.34 - 1.34 Mb
Monopolin complex subunit MAM1
Identifiers
Organism S. cerevisiae
Symbol MAM1
Entrez 856843
RefSeq (mRNA) NM_001178997
RefSeq (Prot) NP_011032
UniProt P40065
Other data
Chromosome V: 0.37 - 0.37 Mb

Monopolin is a protein complex that in yeast is composed of the four proteins CSM1, HRR25, LRS4, and MAM1. Monopolin is required for the segregation of homologous centromeres to opposite poles of a dividing cell during anaphase I of meiosis.[1]

References

  1. ^ Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC (August 2010). "The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments". Cell 142 (4): 556–67. doi:10.1016/j.cell.2010.07.017. PMC 2955198. PMID 20723757. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2955198. 


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