NPT may refer to:
- NPT, the reporting mark of Portland Terminal Railroad of Oregon, United States
- NPT, the former postcode of Newport, Wales, United Kingdom
- NPT, an IATA code of Newport State Airport, Middletown, Rhode Island, United States
- Neighbourhood Policing Team, UK Police term for a group of officers dedicated to policing specific neighbourhoods
- Norwegian Post and Telecommunications Authority, a Norwegian government agency responsible for controlling and regulating the telecommunication and postal services
- NTP, Inc., a Virginia-based patent holding company, best known for its patent case against Research in Motion
- Neath Port Talbot, a county borough and one of the principal areas of Wales, United Kingdom
- Northville-Placid Trail, a lightly travelled foot trail in the Adirondack Park in northern New York, United States
- National pipe thread, a United States standard for tapered threads used to join pipe and fittings
- Nested Page Tables, the former name of Rapid Virtualization Indexing, a hardware-assisted virtualization technology by AMD (Advanced Micro Devices)
- Nissan NPT-90, a racing car developed for Nissan Motors by Nissan Performance Technology Incorporated
- Non-pneumatic tire, another name for an airless tire
- Nepal Time, the time zone of UTC +5:45, used in the Federal Democratic Republic of Nepal in the Himalayas
- Nocturnal Penile Tumescence, a nighttime erection of the penis, an established accompaniment of Rapid Eye Movement sleep
- Nuclear Non-Proliferation Treaty, an international treaty, opened for signature on July 1, 1968 to limit the spread of nuclear weapons
- No-Plane Theory, the theory that no airplanes flew into the World Trade Center on September 11, 2001
- NPT ensemble, a name for the isothermal–isobaric ensemble where the number of particles (N), pressure (P), and temperature (T) of the system are in equilibrium
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