Antianalgesia

Antianalgesia is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects of exogenous analgesics (such as morphine) or endogenous pain inhibiting neurotransmitters/modulators, such as the endogenous opioids. [cite journal | first = EP | last = Wiertelak | coauthors = Maier, SF and Watkins, LR | year = 1992 | month = 8 May | title = Cholecystokinin antianalgesia: safety cues abolish morphine analgesia | journal = Science | volume = 256 | issue = 5058 | pages = 830–833 | doi = 10.1126/science.1589765 | url = http://www.sciencemag.org/cgi/content/abstract/256/5058/830 | accessdate = 2007-02-12 | format = abstract | pmid = 1589765] A learned form can be established using methods similar to the learning principle of conditioned inhibition, and has been demonstrated in rats.

References