MARCKS protein

MARCKS protein

MARCKS proteins (myristoylated alanine-rich C-kinase substrate) play important roles in cell shape, cell motility, secretion, transmembrane transport, and regulation of the cell cycle. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.

They are acidic proteins with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.


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  • Marcks — or MARCKS may refer to: MARCKS, an enzyme encoded by the MARCKS gene MARCKS protein, an acidic protein People with the surname Marcks: Erich Marcks (1891–1944), German general of World War II Gerhard Marcks (1889–1981), German sculptor Greg… …   Wikipedia

  • Protein kinase C — ( PKC , EC number|2.7.11.13) is a family of protein kinases consisting of 10 isozymes.cite journal | author = Mellor H, Parker PJ | title = The extended protein kinase C superfamily | journal = Biochem. J. | volume = 332 ( Pt 2) | issue = | pages …   Wikipedia

  • MARCKS — Myristoylated alanine rich protein kinase C substrate, also known as MARCKS, is a human gene.cite web | title = Entrez Gene: MARCKS myristoylated alanine rich protein kinase C substrate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Protein kinase N1 — Protein kinase N1, also known as PKN1, is a human gene.cite web | title = Entrez Gene: PKN1 protein kinase N1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5585| accessdate = ] PBB Summary section title …   Wikipedia

  • MARCKS — (= myristoylated alanine rich protein kinase C substrate) Membrane associated (through the myristoyl residue) calmodulin and actin binding protein that cycles between membrane and cytoplasm depending on its phosphorylation state and on the… …   Dictionary of molecular biology

  • MARCKS — myristoylated alanine rich protein C kinase substrate …   Medical dictionary

  • MARCKS — • myristoylated alanine rich protein C kinase substrate …   Dictionary of medical acronyms & abbreviations

  • Peripheral membrane protein — Peripheral membrane proteins are proteins that adhere only temporarily to the biological membrane with which they are associated. These molecules attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. The… …   Wikipedia

  • Mucin — Micrograph showing cells with prominent mucin containing intracytoplasmic vacuoles. Pap stain. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans …   Wikipedia

  • MARCKSL1 — MARCKS like 1, also known as MARCKSL1, is a human gene.cite web | title = Entrez Gene: MARCKSL1 MARCKS like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=65108| accessdate = ] PBB Summary section title …   Wikipedia

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