MARCKS

MARCKS

Myristoylated alanine-rich protein kinase C substrate, also known as MARCKS, is a human gene.cite web | title = Entrez Gene: MARCKS myristoylated alanine-rich protein kinase C substrate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4082| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.cite web | title = Entrez Gene: MARCKS myristoylated alanine-rich protein kinase C substrate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4082| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Blackshear PJ |title=The MARCKS family of cellular protein kinase C substrates. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 1501–4 |year= 1993 |pmid= 8420923 |doi=
*cite journal | author=Aderem A |title=The MARCKS family of protein kinase-C substrates. |journal=Biochem. Soc. Trans. |volume=23 |issue= 3 |pages= 587–91 |year= 1996 |pmid= 8566422 |doi=
*cite journal | author=Herget T, Brooks SF, Broad S, Rozengurt E |title=Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. |journal=Eur. J. Biochem. |volume=209 |issue= 1 |pages= 7–14 |year= 1992 |pmid= 1396720 |doi=
*cite journal | author=Sakai K, Hirai M, Kudoh J, "et al." |title=Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. |journal=Genomics |volume=14 |issue= 1 |pages= 175–8 |year= 1992 |pmid= 1427823 |doi=
*cite journal | author=Hartwig JH, Thelen M, Rosen A, "et al." |title=MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. |journal=Nature |volume=356 |issue= 6370 |pages= 618–22 |year= 1992 |pmid= 1560845 |doi= 10.1038/356618a0
*cite journal | author=Harlan DM, Graff JM, Stumpo DJ, "et al." |title=The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14399–405 |year= 1991 |pmid= 1860846 |doi=
*cite journal | author=Graff JM, Stumpo DJ, Blackshear PJ |title=Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C. |journal=J. Biol. Chem. |volume=264 |issue= 20 |pages= 11912–9 |year= 1989 |pmid= 2473066 |doi=
*cite journal | author=Herget T, Oehrlein SA, Pappin DJ, "et al." |title=The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 448–57 |year= 1995 |pmid= 7588787 |doi=
*cite journal | author=Taniguchi H, Manenti S, Suzuki M, Titani K |title=Myristoylated alanine-rich C kinase substrate (MARCKS), a major protein kinase C substrate, is an in vivo substrate of proline-directed protein kinase(s). A mass spectroscopic analysis of the post-translational modifications. |journal=J. Biol. Chem. |volume=269 |issue= 28 |pages= 18299–302 |year= 1994 |pmid= 8034575 |doi=
*cite journal | author=Rao PH, Murty VV, Gaidano G, "et al." |title=Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 4 |pages= 272–3 |year= 1994 |pmid= 8162705 |doi=
*cite journal | author=Taniguchi H, Manenti S |title=Interaction of myristoylated alanine-rich protein kinase C substrate (MARCKS) with membrane phospholipids. |journal=J. Biol. Chem. |volume=268 |issue= 14 |pages= 9960–3 |year= 1993 |pmid= 8486722 |doi=
*cite journal | author=Palmer RH, Schönwasser DC, Rahman D, "et al." |title=PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. |journal=FEBS Lett. |volume=378 |issue= 3 |pages= 281–5 |year= 1996 |pmid= 8557118 |doi=
*cite journal | author=Swierczynski SL, Blackshear PJ |title=Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine-rich protein kinase C substrate protein in intact cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23424–30 |year= 1996 |pmid= 8798548 |doi=
*cite journal | author=Spizz G, Blackshear PJ |title=Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23833–42 |year= 1997 |pmid= 9295331 |doi=
*cite journal | author=Qi Q, Rajala RV, Anderson W, "et al." |title=Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9673–83 |year= 2000 |pmid= 10734119 |doi=
*cite journal | author=Jin Cho S, La M, Ahn JK, "et al." |title=Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 273–7 |year= 2001 |pmid= 11327693 |doi= 10.1006/bbrc.2001.4773
*cite journal | author=Li Y, Martin LD, Spizz G, Adler KB |title=MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40982–90 |year= 2001 |pmid= 11533058 |doi= 10.1074/jbc.M105614200
*cite journal | author=Rauch ME, Ferguson CG, Prestwich GD, Cafiso DS |title=Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14068–76 |year= 2002 |pmid= 11825894 |doi= 10.1074/jbc.M109572200

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  • Marcks — or MARCKS may refer to: MARCKS, an enzyme encoded by the MARCKS gene MARCKS protein, an acidic protein People with the surname Marcks: Erich Marcks (1891–1944), German general of World War II Gerhard Marcks (1889–1981), German sculptor Greg… …   Wikipedia

  • Marcks — ist der Name folgender Personen: Erich Marcks (Historiker) (1861–1938), deutscher Historiker Erich Marcks (General) (1891–1944), deutscher General der Wehrmacht Ernst Marcks (1848?–1905), deutscher Druckereibesitzer und Verleger Gerhard Marcks… …   Deutsch Wikipedia

  • MARCKS (G.) — MARCKS GERHARD (1889 1981) Sculpteur et graveur allemand. Formé à la sculpture auprès de Gaul et de Kolbe, Gerhard Marcks devient professeur à l’école des arts décoratifs de Berlin en 1918 et, de 1919 à 1925, professeur au Bauhaus où il dirige… …   Encyclopédie Universelle

  • Marcks — Marcks, Erich, deutscher Geschichtsforscher, geb. 17. Nov. 1861 in Magdeburg, studierte in Straßburg, Bonn und Berlin, habilitierte sich nach Reisen im Auslande 1887 in Berlin für Geschichte, wurde 1893 als ordentlicher Professor nach Freiburg i …   Meyers Großes Konversations-Lexikon

  • Marcks — Marcks, Erich, Geschichtsforscher, geb. 17. Nov. 1861 in Magdeburg, 1893 Prof. in Freiburg i.Br., 1894 in Leipzig, 1901 in Heidelberg; schrieb: »Die Zusammenkunft von Bayonne« (1889), »Gasp. von Coligny« (Bd. 1, 1892), »Kaiser Wilhelm I.« (5.… …   Kleines Konversations-Lexikon

  • Marcks — Mạrcks,   1) Erich, Historiker, * Magdeburg 17. 11. 1861, ✝ Berlin 22. 11. 1938, Vetter von 2); seit 1893 Professor, zunächst in Freiburg im Breisgau, dann in Leipzig, Heidelberg, Hamburg, München und (1922 28) Berlin. Marcks wurde 1923 …   Universal-Lexikon

  • MARCKS — (= myristoylated alanine rich protein kinase C substrate) Membrane associated (through the myristoyl residue) calmodulin and actin binding protein that cycles between membrane and cytoplasm depending on its phosphorylation state and on the… …   Dictionary of molecular biology

  • Marcks — Markus. Bekannter Namensträger: Gerhard Marcks, deutscher Bildhauer und Grafiker (19./20.Jh.) …   Wörterbuch der deutschen familiennamen

  • Marcks Family Miniature Circus — Artist Isaac Marcks and Donald Marcks Location Playland Not At The Beach, El Cerrito, California The Marcks Family Miniature Circus is a miniature representation of the Sells Floto Circus of the 1930s. It was conceived and originated by Isaac… …   Wikipedia

  • MARCKS protein — MARCKS proteins (myristoylated alanine rich C kinase substrate) play important roles in cell shape, cell motility, secretion, transmembrane transport, and regulation of the cell cycle. Recently, MARCKS has been implicated in the exocytosis of a… …   Wikipedia

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