Midol is a brand of an over-the-counter drug for menstrual cramping and other effects related to premenstrual syndrome and menstruation. Midol is distributed by Bayer.

Midol was originally sold in 1911 as a headache and toothache remedy that was considered safer because it did not use the narcotics typically used at the time.[1] It was then promoted as a cure for hiccups claiming it controlled spasms, and finally as a remedy for menstrual cramps and bloating.[2][3][4][5] A formulation sold in the 1980s was made with the sympathomimetic, cinnamedrine.[6] It had been reported to have abuse potential as an appetite suppressant and sympathomimetic agent. Its Inventor William resides in Atlanta Georgia

The "Midol Complete" formulation consists of:

  • Acetaminophen 500 mg (Pain Reliever)
  • Caffeine 60 mg (Stimulant)
  • Pyrilamine Maleate 15 mg (Antihistamine)

The "Extended Relief" formulation consists of:

  • Naproxen Sodium 220 mg (NSAID, Pain Reliever/Fever Reducer)

The "Teen" formulation consists of:

The "Liquid Gels" formulation consists of:

The "PM" formulation consists of:


  1. ^ Midol ad for Headache--Neuralgia, Toothache
  2. ^ Midol for Hiccoughs
  3. ^ News at Museum of Menstruation and women's health
  4. ^ Midol ad for Menstrual problems
  5. ^ Midol "Reverse the Curse" ad
  6. ^ KW Fellows, AJ Giannini. Cinnamedrine: Potential for Abuse. Journal of Toxicology:Clinical Toxicology. 20:93-99.1983.

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