Pegloticase

Pegloticase
Pegloticase
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a611015
Pregnancy cat.  ?
Legal status  ?
Routes intravenous
Pharmacokinetic data
Bioavailability N/A
Half-life 10–12 days
Identifiers
CAS number 885051-90-1 N
ATC code M04AX02
UNII R581OT55EA YesY
KEGG D09316 YesY
ChEMBL CHEMBL1237025 N
Chemical data
Formula  ?
Mol. mass 497 kDa (polymer-modified tetramer)
 N(what is this?)  (verify)

Pegloticase (trade name Krystexxa, formerly Puricase)[1] is a drug for the treatment of severe, treatment-refractory, chronic gout, developed by Savient Pharmaceuticals.[2][3] In September 2010, the FDA approved pegloticase for marketing in the United States after two clinical trials demonstrated that the drug lowered uric acid levels and reduced deposits of uric acid crystals in joints and soft tissue.

Mechanism of action

Pegloticase is a recombinant porcine-like uricase. Similarly to rasburicase, both enzymes metabolise uric acid to allantoin. This reduces the risk of precipitates, since allantoin is five to ten times more soluble than uric acid.

In contrast to rasburicase, pegloticase is pegylated to increase its elimination half life from about eight hours to ten or twelve days and to decrease the immunogenicity of the foreign uricase protein. This modification allows for an application just once every two to four weeks, making this drug suitable for long-term treatment.[4]

References

  1. ^ Savient to Present Multiple Abstracts At the European League Against Rheumatism (EULAR) 2009 Annual Congress
  2. ^ Statement on a nonproprietary name adopted by the USAN Council
  3. ^ Savient Pharmaceuticals: Uricase
  4. ^ Biggers, K; Scheinfeldt, N (2008). Current Opin. Investig. Drugs 9 (4): 422–429. 

External links

v · d · eAntigout preparations (M04)
Uricosurics
Xanthine oxidase inhibitors
Mitotic inhibitors
Other
Cinchophen • NSAIDs except aspirin • Sevelamer • Urate oxidase (Rasburicase, Pegloticase†)

M: JNT

anat(h/c, u, t, l)/phys

noco(arth/defr/back/soft)/cong, sysi/epon, injr

proc, drug(M01C, M4)


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